TY - JOUR
T1 - Joint effect of alcohol drinking and tobacco smoking on all-cause mortality and premature death in China
T2 - A cohort study
AU - Hongli, Zhang
AU - Bi, Xueyuan
AU - Zheng, Nanbo
AU - Li, Chao
AU - Yan, Kangkang
N1 - Publisher Copyright:
© 2021 Hongli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2021/1
Y1 - 2021/1
N2 - Background Tobacco smoking and alcohol drinking are associated with several diseases, and studies on the joint effects of smoking and drinking are rare. Objective This study investigates the joint effects of tobacco smoking and alcohol drinking on all-cause and premature mortality in a contemporary cohort. Methods The China Health and Retirement Longitudinal Study (CHARLS) is an ongoing nationally representative survey of subjects aged over 45 years in China that was performed every two years for a total of three waves from 2011 to 2015 in China. We used weighted logistic regression models to estimate the joint effects of tobacco smoking and alcohol drinking on all-cause and premature mortality. Results After adjusting for prespecified confounders, the odds ratios (ORs) of all-cause mortality were 1.51 (95% CI: 1.09–2.10) and 1.47 (95% CI: 1.03–2.08) in smokers and smokers/ drinkers, respectively. Compared with nonsmokers/nondrinkers, the OR of smokers/drinkers for premature death was 3.14 (95% CI: 1.56–6.34). In the female subgroup, there was an approximately 5-fold (OR = 4.95; 95% CI: 2.00–12.27) odds of premature mortality for smokers/drinkers compared to nonsmokers/nondrinkers. Conclusion This study found a joint effect of tobacco smoking and alcohol drinking on all-cause and premature mortality among a contemporary and nationally representative cohort in China. Our results suggested that the joint effects were more pronounced in women, but further research is needed.
AB - Background Tobacco smoking and alcohol drinking are associated with several diseases, and studies on the joint effects of smoking and drinking are rare. Objective This study investigates the joint effects of tobacco smoking and alcohol drinking on all-cause and premature mortality in a contemporary cohort. Methods The China Health and Retirement Longitudinal Study (CHARLS) is an ongoing nationally representative survey of subjects aged over 45 years in China that was performed every two years for a total of three waves from 2011 to 2015 in China. We used weighted logistic regression models to estimate the joint effects of tobacco smoking and alcohol drinking on all-cause and premature mortality. Results After adjusting for prespecified confounders, the odds ratios (ORs) of all-cause mortality were 1.51 (95% CI: 1.09–2.10) and 1.47 (95% CI: 1.03–2.08) in smokers and smokers/ drinkers, respectively. Compared with nonsmokers/nondrinkers, the OR of smokers/drinkers for premature death was 3.14 (95% CI: 1.56–6.34). In the female subgroup, there was an approximately 5-fold (OR = 4.95; 95% CI: 2.00–12.27) odds of premature mortality for smokers/drinkers compared to nonsmokers/nondrinkers. Conclusion This study found a joint effect of tobacco smoking and alcohol drinking on all-cause and premature mortality among a contemporary and nationally representative cohort in China. Our results suggested that the joint effects were more pronounced in women, but further research is needed.
UR - https://www.scopus.com/pages/publications/85100298744
U2 - 10.1371/journal.pone.0245670
DO - 10.1371/journal.pone.0245670
M3 - 文章
C2 - 33507950
AN - SCOPUS:85100298744
SN - 1932-6203
VL - 16
JO - PLoS ONE
JF - PLoS ONE
IS - 1
M1 - e0245670
ER -
