@inproceedings{7bad4e278aa24d10a06d42da77abc419,
title = "Isothermal titration calorimetry in a miniaturized 3D-printed platform",
abstract = "Isothermal titration calorimetry can benefit from operating in miniaturized lab-on-a-chip (LOC) platforms since they enable quantitative, low-cost ITC measurements with improved response time, and reduced reagents consumption. In this paper, we present the first demonstration of a miniaturized 3D-printed LOC platform that integrates a polymeric MEMS-based measurement approach for quantitative ITC characterization of biomolecular interactions. The platform design features fully isolated cantilever-like calorimetric measurement structures that reduces thermal mass and improves measurement sensitivity. We demonstrate the utility of the platform with ITC measurements of titrating barium chloride with 18-crown-6 in a practically relevant concentration (0.2 mM) and a reusable manner.",
keywords = "3D Printing, Isothermal Titration Calorimetry, Lab-on-a-chip, Thermoelectric Measurements",
author = "Yuan Jia and Chao Su and Maogang He and Qiao Lin",
note = "Publisher Copyright: {\textcopyright} 17CBMS-0001.; 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
year = "2020",
language = "英语",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "71--72",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
}