Abstract
Objective: To elucidate the molecular mechanism of realgar-induced apoptosis and differentiation of acute promyelocytic leukemia(APL) cell line NB4. Method: The response of NB4 cells to realgar was explored with a cDNA microarray representing 1003 different human genes. Result: The analysis of gene expression profiles indicated that 9 genes were up-regulated and 37 genes were down-regulated. Among the 9 up-regulated genes, 2 genes were involved in proteasome degradation pathway. Conclusion: PSMC2, PSMD1 and ITGB1 genes may play a role in the apoptosis and differentiation of NB4 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 603-604 |
| Number of pages | 2 |
| Journal | Zhongguo Zhongyao Zazhi |
| Volume | 27 |
| Issue number | 8 |
| State | Published - Aug 2002 |
| Externally published | Yes |
Keywords
- Acute
- DNA microarray
- Leukemia
- Promyelocytic
- Realgar