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Interface-Driven Hybrid Materials Based on DNA-Functionalized Gold Nanoparticles

  • University of Waterloo

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations

Abstract

With around 1,000 papers published yearly, DNA-functionalized gold nanoparticles are a useful model system for demonstrating many bionano concepts, exploring fundamental colloidal and materials science problems, and showing various practical applications in sensing, directed assembly of nanoparticles, and targeted drug and gene delivery. The optical, electric, and catalytic properties of gold are nicely combined with the molecular recognition, catalytic, and structure-directing properties of DNA. The rich interfacial interactions between DNA and gold, and between DNA and solution components, have enabled and affected many of their properties. By understanding the interfaces, more controllable, reproducible, and efficient hybrid materials can be designed and new applications envisioned to continue the legacy of this hybrid.

Original languageEnglish
Pages (from-to)825-847
Number of pages23
JournalMatter
Volume1
Issue number4
DOIs
StatePublished - 2 Oct 2019
Externally publishedYes

Keywords

  • biointerfaces
  • biosensors
  • directed assembly
  • drug delivery
  • hybrid nanomaterials

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