Interaction mechanism between bovine serum albumin and polyethylene glycol revealed with elastic light scattering spectroscopy

  • Wen Zhi Zhang
  • , Kuan Zhang
  • , Jian Long Zheng
  • , Hong Shu Chen
  • , Wei Xing Chen
  • , Xin Li Jing

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In order to gain deeper insight into the interaction mechanism between bovine serum albumin (BSA) and polyethylene glycol (PEG), the present work applied elastic light scattering (ELS) spectroscopy to investigate the interaction between BSA and PEG, and explore the effects of concentration and molecular weight of PEG on the interaction at physiological pH. The results showed that the interaction force existed between linear PEG and spherical BSA molecules was mainly hydrogen bonding. In addition, the apparent binding constant of system was evaluated by model calculation.

Original languageEnglish
Title of host publication2013 Spring International Conference on Material Sciences and Technology (MST-S)
Pages43-50
Number of pages8
DOIs
StatePublished - 2013
Event2013 Spring International Conference on Material Sciences and Technology, MST-S 2013 - Wuhan, China
Duration: 31 May 20132 Jun 2013

Publication series

NameAdvanced Materials Research
Volume704
ISSN (Print)1022-6680

Conference

Conference2013 Spring International Conference on Material Sciences and Technology, MST-S 2013
Country/TerritoryChina
CityWuhan
Period31/05/132/06/13

Keywords

  • Binding constant
  • Bovine serum albumin
  • Elastic light scattering spectroscopy
  • Interaction
  • Polyethylene glycol

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