Abstract
Objective: To study the inhibition effect of taspine on mouse S180 sarcoma and its mechanism. Method: The mouse S180 sarcoma model was established and used to observe the antitumor activity of taspine. The microvessel density and protein expressing of the VEGF, bFGF, Bcl-2 and Bax in the tumor were measured by immunohistochemistry. Result: Taspine showed antitumor activity on the mouse S180 sarcoma in a good dose-dependent manner. The inhibition rates on tumor of taspine at low, middle and high concentrations were 39.08% , 43. 99% and 48. 60% , respectively. The microvessel density and protein expressing of the VEGF, bFGF, Bcl-2 and Bax in the tumor were decreased compared with the negative control. The ratio of Bax to Bcl-2 was increased. Conclusion ; Taspine has antitumor effect on the S180 sarcoma, and the mechanism may be through the way of decreasing the expressing of the VEGF, bFGF, Bcl-2 and Bax and inducing the vascular endothelial cell apoptosis.
| Original language | English |
|---|---|
| Pages (from-to) | 953-956 |
| Number of pages | 4 |
| Journal | Zhongguo Zhongyao Zazhi |
| Volume | 32 |
| Issue number | 10 |
| State | Published - May 2007 |
Keywords
- Angiogenesis
- Protein expressing
- S180 sarcoma
- Taspine