Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways

Rui Liu; Runze Yu; Yuxin Cui; Mengying Fan; Bo Wang; Yanmin Zhang

doi:10.2478/acph-2019-0021

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways

Rui Liu
, Runze Yu
, Yuxin Cui
, Mengying Fan
, Bo Wang
, Yanmin Zhang

Health Science Center

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways.

Original language	English
Pages (from-to)	423-431
Number of pages	9
Journal	Acta Pharmaceutica
Volume	69
Issue number	3
DOIs	https://doi.org/10.2478/acph-2019-0021
State	Published - 1 Sep 2019

Keywords

Bel-7402 cells
EphrinB2
TAD1822-7
anti-angiogenesis
migration
proliferation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2478/acph-2019-0021

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title = "Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways",

abstract = "The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways.",

keywords = "Bel-7402 cells, EphrinB2, TAD1822-7, anti-angiogenesis, migration, proliferation",

author = "Rui Liu and Runze Yu and Yuxin Cui and Mengying Fan and Bo Wang and Yanmin Zhang",

note = "Publisher Copyright: {\textcopyright} 2019 Rui Liu et al., published by Sciendo 2019.",

year = "2019",

month = sep,

day = "1",

doi = "10.2478/acph-2019-0021",

language = "英语",

volume = "69",

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journal = "Acta Pharmaceutica",

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T1 - Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways

AU - Liu, Rui

AU - Yu, Runze

AU - Cui, Yuxin

AU - Fan, Mengying

AU - Wang, Bo

AU - Zhang, Yanmin

PY - 2019/9/1

Y1 - 2019/9/1

N2 - The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways.

AB - The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways.

KW - Bel-7402 cells

KW - EphrinB2

KW - TAD1822-7

KW - anti-angiogenesis

KW - migration

KW - proliferation

UR - https://www.scopus.com/pages/publications/85068332577

U2 - 10.2478/acph-2019-0021

DO - 10.2478/acph-2019-0021

M3 - 文章

C2 - 31259732

AN - SCOPUS:85068332577

SN - 1330-0075

VL - 69

SP - 423

EP - 431

JO - Acta Pharmaceutica

JF - Acta Pharmaceutica

IS - 3

ER -

Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways

Abstract

Keywords

UN SDGs

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