Abstract
Objective: To study the inhibitory action of docetaxel (DOC) on the proliferation of HeLa and SiHa cells. Methods: Cell morphological changes were observed with inverted phase contrast microscope. MTT was adopted to test and calculate the cell inhibition ratio. Flow cytometry was used to detect cell cycle. Results: DOC had an obvious concentration-dependent inhibitory effect on the proliferation of both HeLa and SiHa cells. The inhibition ratio of DOC on SiHa was significantly higher than that on HeLa (P<0.05). DOC blocked HeLa at G2/M phase. Under the effect of DOC, the cell cycle of SiHa was not changed much. Conclusion: DOC has an obvious inhibitory action on both HeLa and SiHa cells, which shows a promising prospect of DOC in clinical treatment of cervical cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 260-264 |
| Number of pages | 5 |
| Journal | Academic Journal of Xi'an Jiaotong University |
| Volume | 22 |
| Issue number | 4 |
| State | Published - Nov 2010 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cervical cancer
- Chemotherapy
- Docetaxel
- HeLa
- Proliferation
- SiHa
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