Iminyl Radical-Triggered Intermolecular Distal C(sp                         3                         )-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade

Yu Rui Gu; Xin Hua Duan; Li Chen; Zhi Yong Ma; Pin Gao; Li Na Guo

doi:10.1021/acs.orglett.8b03865

Iminyl Radical-Triggered Intermolecular Distal C(sp ³ )-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade

Yu Rui Gu
, Xin Hua Duan
, Li Chen
, Zhi Yong Ma
, Pin Gao
, Li Na Guo

School of Chemistry

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

An efficient iron-catalyzed intermolecular remote C(sp ³ )-H heteroarylation of alkyl ketones has been developed via an iminyl radical-triggered 1,5-hydrogen-atom transfer (HAT) cascade. This protocol was amenable to a wide variety of alkyl ketones and heteroaryls, thus providing a straightforward method for the late-stage functionalization of alkylketones and heteroaryls.

Original language	English
Pages (from-to)	917-920
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.8b03865
State	Published - 15 Feb 2019

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10.1021/acs.orglett.8b03865

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title = " Iminyl Radical-Triggered Intermolecular Distal C(sp 3 )-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade ",

abstract = " An efficient iron-catalyzed intermolecular remote C(sp 3 )-H heteroarylation of alkyl ketones has been developed via an iminyl radical-triggered 1,5-hydrogen-atom transfer (HAT) cascade. This protocol was amenable to a wide variety of alkyl ketones and heteroaryls, thus providing a straightforward method for the late-stage functionalization of alkylketones and heteroaryls.",

author = "Gu, \{Yu Rui\} and Duan, \{Xin Hua\} and Li Chen and Ma, \{Zhi Yong\} and Pin Gao and Guo, \{Li Na\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = feb,

day = "15",

doi = "10.1021/acs.orglett.8b03865",

language = "英语",

volume = "21",

pages = "917--920",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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Iminyl Radical-Triggered Intermolecular Distal C(sp ³ )-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade . / Gu, Yu Rui; Duan, Xin Hua; Chen, Li et al.
In: Organic Letters, Vol. 21, No. 4, 15.02.2019, p. 917-920.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Iminyl Radical-Triggered Intermolecular Distal C(sp 3 )-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade

AU - Gu, Yu Rui

AU - Duan, Xin Hua

AU - Chen, Li

AU - Ma, Zhi Yong

AU - Gao, Pin

AU - Guo, Li Na

PY - 2019/2/15

Y1 - 2019/2/15

N2 - An efficient iron-catalyzed intermolecular remote C(sp 3 )-H heteroarylation of alkyl ketones has been developed via an iminyl radical-triggered 1,5-hydrogen-atom transfer (HAT) cascade. This protocol was amenable to a wide variety of alkyl ketones and heteroaryls, thus providing a straightforward method for the late-stage functionalization of alkylketones and heteroaryls.

AB - An efficient iron-catalyzed intermolecular remote C(sp 3 )-H heteroarylation of alkyl ketones has been developed via an iminyl radical-triggered 1,5-hydrogen-atom transfer (HAT) cascade. This protocol was amenable to a wide variety of alkyl ketones and heteroaryls, thus providing a straightforward method for the late-stage functionalization of alkylketones and heteroaryls.

UR - https://www.scopus.com/pages/publications/85061240755

U2 - 10.1021/acs.orglett.8b03865

DO - 10.1021/acs.orglett.8b03865

M3 - 文章

C2 - 30688076

AN - SCOPUS:85061240755

SN - 1523-7060

VL - 21

SP - 917

EP - 920

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Iminyl Radical-Triggered Intermolecular Distal C(sp ³ )-H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade

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