H2O2-driven enzymatic oxyfunctionalization of tertiary C-H bonds

Yawen Huang; Huanhuan Li; Pengpeng Zhang; Yalan Zhang; Peigao Duan; Wuyuan Zhang

doi:10.1039/d3cc02925e

H₂O₂-driven enzymatic oxyfunctionalization of tertiary C-H bonds

Yawen Huang
, Huanhuan Li
, Pengpeng Zhang
, Yalan Zhang
, Peigao Duan
, Wuyuan Zhang

School of Chemical Engineering and Technology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.

Original language	English
Pages (from-to)	9219-9222
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	60
DOIs	https://doi.org/10.1039/d3cc02925e
State	Published - 3 Jul 2023

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10.1039/d3cc02925e

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title = "H2O2-driven enzymatic oxyfunctionalization of tertiary C-H bonds",

abstract = "Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.",

author = "Yawen Huang and Huanhuan Li and Pengpeng Zhang and Yalan Zhang and Peigao Duan and Wuyuan Zhang",

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T1 - H2O2-driven enzymatic oxyfunctionalization of tertiary C-H bonds

AU - Huang, Yawen

AU - Li, Huanhuan

AU - Zhang, Pengpeng

AU - Zhang, Yalan

AU - Duan, Peigao

AU - Zhang, Wuyuan

PY - 2023/7/3

Y1 - 2023/7/3

N2 - Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.

AB - Peroxygenase from Agrocybe aegerita catalyses the selective hydroxylation of tertiary C-H bonds, whereby tertiary alcohols, diols, ketols, etc., were obtained in good to high regioselectivity and turnover numbers. This method can also be expanded for late-stage functionalization of drug molecules, which represents a streamlined synthetic method to give access to useful compounds.

UR - https://www.scopus.com/pages/publications/85165430502

U2 - 10.1039/d3cc02925e

DO - 10.1039/d3cc02925e

M3 - 文章

C2 - 37416971

AN - SCOPUS:85165430502

SN - 1359-7345

VL - 59

SP - 9219

EP - 9222

JO - Chemical Communications

JF - Chemical Communications

IS - 60

ER -

H₂O₂-driven enzymatic oxyfunctionalization of tertiary C-H bonds

Abstract

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