Horizontoates A-C: New cholinesterase inhibitors from Cotoneaster horizontalis

Shafiullah Khan; Zhao Wang; Runguo Wang; Liqun Zhang

doi:10.1016/j.phytol.2014.09.007

Horizontoates A-C: New cholinesterase inhibitors from Cotoneaster horizontalis

Shafiullah Khan
, Zhao Wang
, Runguo Wang
, Liqun Zhang

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Two new aromatic esters Horizontoate A (=4-(2-methylhexyl)oxy)carbonyl)benzoic acid; 1) and B (=2-methylpentyl 4-methoxybenzoate; 2), along with one new sphingolipid C (=(Z)-N-((2S,3S,4R)-1,3,4-trihydroxyhexadecan-2-yl)tridec-10-enamide; 3), were isolated from Cotoneaster horizontalis Decne. Their structures were elucidated by chemical and spectroscopic techniques. Compounds 1 and 2 showed significant inhibitory effects on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner, while compound 3 was found inactive. The IC₅₀ values of compounds 1 and 2 were 1.54 and 3.41 μM against AChE and 5.97 and 6.84 μM against BChE.

Original language	English
Pages (from-to)	204-208
Number of pages	5
Journal	Phytochemistry Letters
Volume	10
DOIs	https://doi.org/10.1016/j.phytol.2014.09.007
State	Published - Dec 2014
Externally published	Yes

Keywords

B (2) and C (3)
Cholinesterase inhibitors
Cotoneaster horizontalis
Horizonatoate A (1)
Isolation

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10.1016/j.phytol.2014.09.007

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@article{ffb0f9e92447425c8b83e57d09c3d6ea,

title = "Horizontoates A-C: New cholinesterase inhibitors from Cotoneaster horizontalis",

abstract = "Two new aromatic esters Horizontoate A (=4-(2-methylhexyl)oxy)carbonyl)benzoic acid; 1) and B (=2-methylpentyl 4-methoxybenzoate; 2), along with one new sphingolipid C (=(Z)-N-((2S,3S,4R)-1,3,4-trihydroxyhexadecan-2-yl)tridec-10-enamide; 3), were isolated from Cotoneaster horizontalis Decne. Their structures were elucidated by chemical and spectroscopic techniques. Compounds 1 and 2 showed significant inhibitory effects on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner, while compound 3 was found inactive. The IC50 values of compounds 1 and 2 were 1.54 and 3.41 μM against AChE and 5.97 and 6.84 μM against BChE.",

keywords = "B (2) and C (3), Cholinesterase inhibitors, Cotoneaster horizontalis, Horizonatoate A (1), Isolation",

author = "Shafiullah Khan and Zhao Wang and Runguo Wang and Liqun Zhang",

year = "2014",

month = dec,

doi = "10.1016/j.phytol.2014.09.007",

language = "英语",

volume = "10",

pages = "204--208",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Horizontoates A-C

T2 - New cholinesterase inhibitors from Cotoneaster horizontalis

AU - Khan, Shafiullah

AU - Wang, Zhao

AU - Wang, Runguo

AU - Zhang, Liqun

PY - 2014/12

Y1 - 2014/12

N2 - Two new aromatic esters Horizontoate A (=4-(2-methylhexyl)oxy)carbonyl)benzoic acid; 1) and B (=2-methylpentyl 4-methoxybenzoate; 2), along with one new sphingolipid C (=(Z)-N-((2S,3S,4R)-1,3,4-trihydroxyhexadecan-2-yl)tridec-10-enamide; 3), were isolated from Cotoneaster horizontalis Decne. Their structures were elucidated by chemical and spectroscopic techniques. Compounds 1 and 2 showed significant inhibitory effects on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner, while compound 3 was found inactive. The IC50 values of compounds 1 and 2 were 1.54 and 3.41 μM against AChE and 5.97 and 6.84 μM against BChE.

AB - Two new aromatic esters Horizontoate A (=4-(2-methylhexyl)oxy)carbonyl)benzoic acid; 1) and B (=2-methylpentyl 4-methoxybenzoate; 2), along with one new sphingolipid C (=(Z)-N-((2S,3S,4R)-1,3,4-trihydroxyhexadecan-2-yl)tridec-10-enamide; 3), were isolated from Cotoneaster horizontalis Decne. Their structures were elucidated by chemical and spectroscopic techniques. Compounds 1 and 2 showed significant inhibitory effects on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner, while compound 3 was found inactive. The IC50 values of compounds 1 and 2 were 1.54 and 3.41 μM against AChE and 5.97 and 6.84 μM against BChE.

KW - B (2) and C (3)

KW - Cholinesterase inhibitors

KW - Cotoneaster horizontalis

KW - Horizonatoate A (1)

KW - Isolation

UR - https://www.scopus.com/pages/publications/84907886864

U2 - 10.1016/j.phytol.2014.09.007

DO - 10.1016/j.phytol.2014.09.007

M3 - 文章

AN - SCOPUS:84907886864

SN - 1874-3900

VL - 10

SP - 204

EP - 208

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Horizontoates A-C: New cholinesterase inhibitors from Cotoneaster horizontalis

Abstract

Keywords

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