HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China

G. Yang; Y. J. Deng; S. N. Hu; D. Y. Wu; S. B. Li; J. Zhu; B. F. Zhu; Y. Liu

doi:10.1111/j.1399-0039.2006.00529.x

HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China

G. Yang
, Y. J. Deng
, S. N. Hu
, D. Y. Wu
, S. B. Li
, J. Zhu
, B. F. Zhu
, Y. Liu

Health Science Center

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

DNA typing for human leukocyte antigen (HLA)-A, -B and -DRB1 was performed using polymerase chain reaction-sequence-based typing method on 618 randomly selected healthy individuals of the Han population in Northern China. Allele frequencies and haplotypes were statistically analyzed. A total of 84 HLA-A alleles, 143 B alleles, and 122 DRB1 alleles were detected, and 853 A-B-DRB1 haplotypes, 473 A-B haplotypes, and 551 B-DRB1 haplotypes were statistically inferred. Statistical analysis of three-locus haplotypes showed that A*0207-B*4601-DRB1*0901 (3.06%) was the most predominant. Gene frequencies and haplotypic associations within HLA-A, -B, and -DRB1 loci were determined at a high-resolution (four digit) allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies.

Original language	English
Pages (from-to)	146-152
Number of pages	7
Journal	Tissue Antigens
Volume	67
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-0039.2006.00529.x
State	Published - Feb 2006

Keywords

Allele frequencies
HLA
Han population
Haplotype frequencies
Northern China
PCR-SBT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1399-0039.2006.00529.x

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title = "HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China",

abstract = "DNA typing for human leukocyte antigen (HLA)-A, -B and -DRB1 was performed using polymerase chain reaction-sequence-based typing method on 618 randomly selected healthy individuals of the Han population in Northern China. Allele frequencies and haplotypes were statistically analyzed. A total of 84 HLA-A alleles, 143 B alleles, and 122 DRB1 alleles were detected, and 853 A-B-DRB1 haplotypes, 473 A-B haplotypes, and 551 B-DRB1 haplotypes were statistically inferred. Statistical analysis of three-locus haplotypes showed that A*0207-B*4601-DRB1*0901 (3.06\%) was the most predominant. Gene frequencies and haplotypic associations within HLA-A, -B, and -DRB1 loci were determined at a high-resolution (four digit) allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies.",

keywords = "Allele frequencies, HLA, Han population, Haplotype frequencies, Northern China, PCR-SBT",

author = "G. Yang and Deng, \{Y. J.\} and Hu, \{S. N.\} and Wu, \{D. Y.\} and Li, \{S. B.\} and J. Zhu and Zhu, \{B. F.\} and Y. Liu",

year = "2006",

month = feb,

doi = "10.1111/j.1399-0039.2006.00529.x",

language = "英语",

volume = "67",

pages = "146--152",

journal = "Tissue Antigens",

issn = "0001-2815",

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TY - JOUR

T1 - HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China

AU - Yang, G.

AU - Deng, Y. J.

AU - Hu, S. N.

AU - Wu, D. Y.

AU - Li, S. B.

AU - Zhu, J.

AU - Zhu, B. F.

AU - Liu, Y.

PY - 2006/2

Y1 - 2006/2

N2 - DNA typing for human leukocyte antigen (HLA)-A, -B and -DRB1 was performed using polymerase chain reaction-sequence-based typing method on 618 randomly selected healthy individuals of the Han population in Northern China. Allele frequencies and haplotypes were statistically analyzed. A total of 84 HLA-A alleles, 143 B alleles, and 122 DRB1 alleles were detected, and 853 A-B-DRB1 haplotypes, 473 A-B haplotypes, and 551 B-DRB1 haplotypes were statistically inferred. Statistical analysis of three-locus haplotypes showed that A*0207-B*4601-DRB1*0901 (3.06%) was the most predominant. Gene frequencies and haplotypic associations within HLA-A, -B, and -DRB1 loci were determined at a high-resolution (four digit) allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies.

AB - DNA typing for human leukocyte antigen (HLA)-A, -B and -DRB1 was performed using polymerase chain reaction-sequence-based typing method on 618 randomly selected healthy individuals of the Han population in Northern China. Allele frequencies and haplotypes were statistically analyzed. A total of 84 HLA-A alleles, 143 B alleles, and 122 DRB1 alleles were detected, and 853 A-B-DRB1 haplotypes, 473 A-B haplotypes, and 551 B-DRB1 haplotypes were statistically inferred. Statistical analysis of three-locus haplotypes showed that A*0207-B*4601-DRB1*0901 (3.06%) was the most predominant. Gene frequencies and haplotypic associations within HLA-A, -B, and -DRB1 loci were determined at a high-resolution (four digit) allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies.

KW - Allele frequencies

KW - HLA

KW - Han population

KW - Haplotype frequencies

KW - Northern China

KW - PCR-SBT

UR - https://www.scopus.com/pages/publications/33644922690

U2 - 10.1111/j.1399-0039.2006.00529.x

DO - 10.1111/j.1399-0039.2006.00529.x

M3 - 文章

C2 - 16441486

AN - SCOPUS:33644922690

SN - 0001-2815

VL - 67

SP - 146

EP - 152

JO - Tissue Antigens

JF - Tissue Antigens

IS - 2

ER -

HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China

Abstract

Keywords

UN SDGs

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