HINT1 is involved in the behavioral abnormalities induced by social isolation rearing

Yong hui Dang; Peng Liu; Rui Ma; Zheng Chu; You ping Liu; Jia bei Wang; Xian cang Ma; Cheng ge Gao

doi:10.1016/j.neulet.2015.08.026

HINT1 is involved in the behavioral abnormalities induced by social isolation rearing

Yong hui Dang
, Peng Liu
, Rui Ma
, Zheng Chu
, You ping Liu
, Jia bei Wang
, Xian cang Ma
, Cheng ge Gao

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Social isolation (SI) rearing has been demonstrated to induce behavioral abnormalities like anxiety, impulsivity, aggression, and learning and memory deficits which are relevant to core symptoms in patients with some certain neuropsychiatric disorders. But the underlying pathophysiological mechanisms remain unclear. Recent studies have revealed HINT1 has close relation with diverse neuropsychiatric diseases. In this present study, the SI rearing mice exhibited depression-like and aggressive behavior. Besides, HINT1 protein levels decreased in PFC but increased in HIP. Based on the data obtained, we concluded that HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Neuroscience Letters
Volume	607
DOIs	https://doi.org/10.1016/j.neulet.2015.08.026
State	Published - 21 Oct 2015
Externally published	Yes

Keywords

Aggressive behavior
HINT1
Hippocampus
Prefrontal cortex
Social isolation

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10.1016/j.neulet.2015.08.026

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title = "HINT1 is involved in the behavioral abnormalities induced by social isolation rearing",

abstract = "Social isolation (SI) rearing has been demonstrated to induce behavioral abnormalities like anxiety, impulsivity, aggression, and learning and memory deficits which are relevant to core symptoms in patients with some certain neuropsychiatric disorders. But the underlying pathophysiological mechanisms remain unclear. Recent studies have revealed HINT1 has close relation with diverse neuropsychiatric diseases. In this present study, the SI rearing mice exhibited depression-like and aggressive behavior. Besides, HINT1 protein levels decreased in PFC but increased in HIP. Based on the data obtained, we concluded that HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.",

keywords = "Aggressive behavior, HINT1, Hippocampus, Prefrontal cortex, Social isolation",

author = "Dang, \{Yong hui\} and Peng Liu and Rui Ma and Zheng Chu and Liu, \{You ping\} and Wang, \{Jia bei\} and Ma, \{Xian cang\} and Gao, \{Cheng ge\}",

note = "Publisher Copyright: {\textcopyright} 2015 Published by Elsevier Ireland Ltd.",

year = "2015",

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doi = "10.1016/j.neulet.2015.08.026",

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T1 - HINT1 is involved in the behavioral abnormalities induced by social isolation rearing

AU - Dang, Yong hui

AU - Liu, Peng

AU - Ma, Rui

AU - Chu, Zheng

AU - Liu, You ping

AU - Wang, Jia bei

AU - Ma, Xian cang

AU - Gao, Cheng ge

PY - 2015/10/21

Y1 - 2015/10/21

N2 - Social isolation (SI) rearing has been demonstrated to induce behavioral abnormalities like anxiety, impulsivity, aggression, and learning and memory deficits which are relevant to core symptoms in patients with some certain neuropsychiatric disorders. But the underlying pathophysiological mechanisms remain unclear. Recent studies have revealed HINT1 has close relation with diverse neuropsychiatric diseases. In this present study, the SI rearing mice exhibited depression-like and aggressive behavior. Besides, HINT1 protein levels decreased in PFC but increased in HIP. Based on the data obtained, we concluded that HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.

AB - Social isolation (SI) rearing has been demonstrated to induce behavioral abnormalities like anxiety, impulsivity, aggression, and learning and memory deficits which are relevant to core symptoms in patients with some certain neuropsychiatric disorders. But the underlying pathophysiological mechanisms remain unclear. Recent studies have revealed HINT1 has close relation with diverse neuropsychiatric diseases. In this present study, the SI rearing mice exhibited depression-like and aggressive behavior. Besides, HINT1 protein levels decreased in PFC but increased in HIP. Based on the data obtained, we concluded that HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.

KW - Aggressive behavior

KW - HINT1

KW - Hippocampus

KW - Prefrontal cortex

KW - Social isolation

UR - https://www.scopus.com/pages/publications/84942520325

U2 - 10.1016/j.neulet.2015.08.026

DO - 10.1016/j.neulet.2015.08.026

M3 - 文章

C2 - 26300541

AN - SCOPUS:84942520325

SN - 0304-3940

VL - 607

SP - 40

EP - 45

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

HINT1 is involved in the behavioral abnormalities induced by social isolation rearing

Abstract

Keywords

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