TY - JOUR
T1 - Highly Emissive AIEgens with Multiple Functions
T2 - Facile Synthesis, Chromism, Specific Lipid Droplet Imaging, Apoptosis Monitoring, and in Vivo Imaging
AU - Dang, Dongfeng
AU - Liu, Haixiang
AU - Wang, Jianguo
AU - Chen, Ming
AU - Liu, Yong
AU - Sung, Herman H.Y.
AU - Williams, Ian D.
AU - Kwok, Ryan T.K.
AU - Lam, Jacky W.Y.
AU - Tang, Ben Zhong
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/11/13
Y1 - 2018/11/13
N2 - The development of new luminescent materials has allowed us to gain new knowledge and opened a new opportunity for scientific achievement and social development. In this work, luminogens, namely, (4-pyridinyl)-phenyldiphenylamine (TPAP) and 3-diphenylamino-6-(2-pyridinyl)phenyldiphenylboron (TPAP-BB), were synthesized in satisfactory yields through convenient synthetic routes and their properties were systematically investigated. These luminogens exhibited a moderate fluorescence quantum yield in tetrahydrofuran (14.6% for TPAP and 49.0% for TPAP-BB), whereas their values in thin films were much higher (69.4% and 88.4%), demonstrating a phenomenon of aggregation-induced emission (AIE). Moreover, TPAP-BB not only exhibited piezo-chromism (its emission color could be tuned repeatedly by grinding-heating cycle because of the transformation between crystalline and amorphous phases) but also showed on-off light emission process by repeatedly fuming with acid and ammonia vapor. Furthermore, TPAP-BB exhibited impressive high photostability and low toxicity to living cells. It could specifically stain lipid droplets (LDs) in live HeLa cells with higher signal-to-noise ratio than Nile Red, a commercial LDs agent. This dye could also be applied for real-time monitoring of cell apoptosis and in vivo imaging in Medaka fish. Such results were expected to create enthusiasm to generate new AIE luminogens for further technological applications.
AB - The development of new luminescent materials has allowed us to gain new knowledge and opened a new opportunity for scientific achievement and social development. In this work, luminogens, namely, (4-pyridinyl)-phenyldiphenylamine (TPAP) and 3-diphenylamino-6-(2-pyridinyl)phenyldiphenylboron (TPAP-BB), were synthesized in satisfactory yields through convenient synthetic routes and their properties were systematically investigated. These luminogens exhibited a moderate fluorescence quantum yield in tetrahydrofuran (14.6% for TPAP and 49.0% for TPAP-BB), whereas their values in thin films were much higher (69.4% and 88.4%), demonstrating a phenomenon of aggregation-induced emission (AIE). Moreover, TPAP-BB not only exhibited piezo-chromism (its emission color could be tuned repeatedly by grinding-heating cycle because of the transformation between crystalline and amorphous phases) but also showed on-off light emission process by repeatedly fuming with acid and ammonia vapor. Furthermore, TPAP-BB exhibited impressive high photostability and low toxicity to living cells. It could specifically stain lipid droplets (LDs) in live HeLa cells with higher signal-to-noise ratio than Nile Red, a commercial LDs agent. This dye could also be applied for real-time monitoring of cell apoptosis and in vivo imaging in Medaka fish. Such results were expected to create enthusiasm to generate new AIE luminogens for further technological applications.
UR - https://www.scopus.com/pages/publications/85055095952
U2 - 10.1021/acs.chemmater.8b03495
DO - 10.1021/acs.chemmater.8b03495
M3 - 文章
AN - SCOPUS:85055095952
SN - 0897-4756
VL - 30
SP - 7892
EP - 7901
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 21
ER -