Hepatobiliary transport of glutathione and its role in cholestasis

Xue Ying Zhang; Jin Yang; Xue Fen Yin; Xiao Dong Liu; Guang Ji Wang

Hepatobiliary transport of glutathione and its role in cholestasis

Xue Ying Zhang
, Jin Yang
, Xue Fen Yin
, Xiao Dong Liu
, Guang Ji Wang

China Pharmaceutical University

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.

Original language	English
Pages (from-to)	327-332
Number of pages	6
Journal	Yaoxue Xuebao
Volume	44
Issue number	4
State	Published - Apr 2009
Externally published	Yes

Keywords

Cholestasis
Glutathione
Hepatobiliary transport
Multidrug resistance associated protein

Cite this

@article{f8389b0c1bd14c85bb13d99831fdfaef,

title = "Hepatobiliary transport of glutathione and its role in cholestasis",

abstract = "Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.",

keywords = "Cholestasis, Glutathione, Hepatobiliary transport, Multidrug resistance associated protein",

author = "Zhang, \{Xue Ying\} and Jin Yang and Yin, \{Xue Fen\} and Liu, \{Xiao Dong\} and Wang, \{Guang Ji\}",

year = "2009",

month = apr,

language = "英语",

volume = "44",

pages = "327--332",

journal = "Yaoxue Xuebao",

issn = "0513-4870",

publisher = "Chinese Pharmaceutical Association",

number = "4",

}

TY - JOUR

T1 - Hepatobiliary transport of glutathione and its role in cholestasis

AU - Zhang, Xue Ying

AU - Yang, Jin

AU - Yin, Xue Fen

AU - Liu, Xiao Dong

AU - Wang, Guang Ji

PY - 2009/4

Y1 - 2009/4

N2 - Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.

AB - Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.

KW - Cholestasis

KW - Glutathione

KW - Hepatobiliary transport

KW - Multidrug resistance associated protein

UR - https://www.scopus.com/pages/publications/64949186047

M3 - 文献综述

C2 - 19545046

AN - SCOPUS:64949186047

SN - 0513-4870

VL - 44

SP - 327

EP - 332

JO - Yaoxue Xuebao

JF - Yaoxue Xuebao

IS - 4

ER -

Hepatobiliary transport of glutathione and its role in cholestasis

Abstract

Keywords

Other files and links

Fingerprint

Cite this