Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

Zhuo Zhou; Lili Ren; Li Zhang; Jiaxin Zhong; Yan Xiao; Zhilong Jia; Li Guo; Jing Yang; Chun Wang; Shuai Jiang; Donghong Yang; Guoliang Zhang; Hongru Li; Fuhui Chen; Yu Xu; Mingwei Chen; Zhancheng Gao; Jian Yang; Jie Dong; Bo Liu; Xiannian Zhang; Weidong Wang; Kunlun He; Qi Jin; Mingkun Li; Jianwei Wang

doi:10.1016/j.chom.2020.04.017

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

Zhuo Zhou
, Lili Ren
, Li Zhang
, Jiaxin Zhong
, Yan Xiao
, Zhilong Jia
, Li Guo
, Jing Yang
, Chun Wang
, Shuai Jiang
, Donghong Yang
, Guoliang Zhang
, Hongru Li
, Fuhui Chen
, Yu Xu
, Mingwei Chen
, Zhancheng Gao
, Jian Yang
, Jie Dong
, Bo Liu

Xiannian Zhang, Weidong Wang, Kunlun He, Qi Jin, Mingkun Li, Jianwei Wang

Research output: Contribution to journal › Article › peer-review

777 Scopus citations

Abstract

Zhou et al. use metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of COVID-19 patients. COVID-19 patients exhibit robust innate immune responses with notable hypercytokinemia and increased expression of IFN-stimulated genes. This analysis provides timely information for understanding SARS-CoV-2-host interactions and COVID-19 pathogenesis.

Original language	English
Pages (from-to)	883-890.e2
Journal	Cell Host and Microbe
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2020.04.017
State	Published - 10 Jun 2020
Externally published	Yes

Keywords

Bronchoalveolar lavage fluid
COVID-19
Chemokines
Coronavirus
Hypercytokinemia
Innate immune response
Interferon response
Interferon-stimulated genes
Metatranscriptomic sequencing
SARS-CoV-2

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10.1016/j.chom.2020.04.017

Cite this

Zhou, Z., Ren, L., Zhang, L., Zhong, J., Xiao, Y., Jia, Z., Guo, L., Yang, J., Wang, C., Jiang, S., Yang, D., Zhang, G., Li, H., Chen, F., Xu, Y., Chen, M., Gao, Z., Yang, J., Dong, J., ... Wang, J. (2020). Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Cell Host and Microbe, 27(6), 883-890.e2. https://doi.org/10.1016/j.chom.2020.04.017

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title = "Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients",

abstract = "Zhou et al. use metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of COVID-19 patients. COVID-19 patients exhibit robust innate immune responses with notable hypercytokinemia and increased expression of IFN-stimulated genes. This analysis provides timely information for understanding SARS-CoV-2-host interactions and COVID-19 pathogenesis.",

keywords = "Bronchoalveolar lavage fluid, COVID-19, Chemokines, Coronavirus, Hypercytokinemia, Innate immune response, Interferon response, Interferon-stimulated genes, Metatranscriptomic sequencing, SARS-CoV-2",

author = "Zhuo Zhou and Lili Ren and Li Zhang and Jiaxin Zhong and Yan Xiao and Zhilong Jia and Li Guo and Jing Yang and Chun Wang and Shuai Jiang and Donghong Yang and Guoliang Zhang and Hongru Li and Fuhui Chen and Yu Xu and Mingwei Chen and Zhancheng Gao and Jian Yang and Jie Dong and Bo Liu and Xiannian Zhang and Weidong Wang and Kunlun He and Qi Jin and Mingkun Li and Jianwei Wang",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jun,

day = "10",

doi = "10.1016/j.chom.2020.04.017",

language = "英语",

volume = "27",

pages = "883--890.e2",

journal = "Cell Host and Microbe",

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Zhou, Z, Ren, L, Zhang, L, Zhong, J, Xiao, Y, Jia, Z, Guo, L, Yang, J, Wang, C, Jiang, S, Yang, D, Zhang, G, Li, H, Chen, F, Xu, Y, Chen, M, Gao, Z, Yang, J, Dong, J, Liu, B, Zhang, X, Wang, W, He, K, Jin, Q, Li, M & Wang, J 2020, 'Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients', Cell Host and Microbe, vol. 27, no. 6, pp. 883-890.e2. https://doi.org/10.1016/j.chom.2020.04.017

TY - JOUR

T1 - Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

AU - Zhou, Zhuo

AU - Ren, Lili

AU - Zhang, Li

AU - Zhong, Jiaxin

AU - Xiao, Yan

AU - Jia, Zhilong

AU - Guo, Li

AU - Yang, Jing

AU - Wang, Chun

AU - Jiang, Shuai

AU - Yang, Donghong

AU - Zhang, Guoliang

AU - Li, Hongru

AU - Chen, Fuhui

AU - Xu, Yu

AU - Chen, Mingwei

AU - Gao, Zhancheng

AU - Yang, Jian

AU - Dong, Jie

AU - Liu, Bo

AU - Zhang, Xiannian

AU - Wang, Weidong

AU - He, Kunlun

AU - Jin, Qi

AU - Li, Mingkun

AU - Wang, Jianwei

PY - 2020/6/10

Y1 - 2020/6/10

N2 - Zhou et al. use metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of COVID-19 patients. COVID-19 patients exhibit robust innate immune responses with notable hypercytokinemia and increased expression of IFN-stimulated genes. This analysis provides timely information for understanding SARS-CoV-2-host interactions and COVID-19 pathogenesis.

AB - Zhou et al. use metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of COVID-19 patients. COVID-19 patients exhibit robust innate immune responses with notable hypercytokinemia and increased expression of IFN-stimulated genes. This analysis provides timely information for understanding SARS-CoV-2-host interactions and COVID-19 pathogenesis.

KW - Bronchoalveolar lavage fluid

KW - COVID-19

KW - Chemokines

KW - Coronavirus

KW - Hypercytokinemia

KW - Innate immune response

KW - Interferon response

KW - Interferon-stimulated genes

KW - Metatranscriptomic sequencing

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85084457061

U2 - 10.1016/j.chom.2020.04.017

DO - 10.1016/j.chom.2020.04.017

M3 - 文章

C2 - 32407669

AN - SCOPUS:85084457061

SN - 1931-3128

VL - 27

SP - 883-890.e2

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

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