Gold nanostars decorated MnO2 nanosheets for magnetic resonance imaging and photothermal erasion of lung cancer cell

Jing Liu; Hongbo Cui; Siyu Yan; Xunan Jing; Daquan Wang; Lingjie Meng

doi:10.1016/j.mtcomm.2018.04.012

Gold nanostars decorated MnO₂ nanosheets for magnetic resonance imaging and photothermal erasion of lung cancer cell

Jing Liu
, Hongbo Cui
, Siyu Yan
, Xunan Jing
, Daquan Wang
, Lingjie Meng

School of Chemistry

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We report a facile fabrication approach for sensitive theranostic nanoprobe - gold nanostars@MnO₂ nanosheets, by which gold nanostars were grown on the surface of MnO₂ nanosheets. Owing to the ability of gold nanostars to absorb light at near infrared (NIR) wavelength, the nanoprobe showed excellent photothermal conversion effect, while exhibited tumor microenvironment-responsive magnetic resonance imaging property due to the redox property of MnO₂ nanosheets. Amazingly, photothermal irradiation experiment showed that the nanoprobe sensitively triggered lung cancer cell death, while produced negligible effect on normal lung epithelial cells. Therefore, these demonstrate that the nanoprobe may have potential application in magnetic resonance imaging-guided photothermal therapy of lung cancer.

Original language	English
Pages (from-to)	97-104
Number of pages	8
Journal	Materials Today Communications
Volume	16
DOIs	https://doi.org/10.1016/j.mtcomm.2018.04.012
State	Published - Sep 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gold nanostars
Lung cancer
Magnetic resonance imaging
MnO nanosheets
Photothermal therapy

Access to Document

10.1016/j.mtcomm.2018.04.012

Cite this

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title = "Gold nanostars decorated MnO2 nanosheets for magnetic resonance imaging and photothermal erasion of lung cancer cell",

abstract = "We report a facile fabrication approach for sensitive theranostic nanoprobe - gold nanostars@MnO2 nanosheets, by which gold nanostars were grown on the surface of MnO2 nanosheets. Owing to the ability of gold nanostars to absorb light at near infrared (NIR) wavelength, the nanoprobe showed excellent photothermal conversion effect, while exhibited tumor microenvironment-responsive magnetic resonance imaging property due to the redox property of MnO2 nanosheets. Amazingly, photothermal irradiation experiment showed that the nanoprobe sensitively triggered lung cancer cell death, while produced negligible effect on normal lung epithelial cells. Therefore, these demonstrate that the nanoprobe may have potential application in magnetic resonance imaging-guided photothermal therapy of lung cancer.",

keywords = "Gold nanostars, Lung cancer, Magnetic resonance imaging, MnO nanosheets, Photothermal therapy",

author = "Jing Liu and Hongbo Cui and Siyu Yan and Xunan Jing and Daquan Wang and Lingjie Meng",

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year = "2018",

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doi = "10.1016/j.mtcomm.2018.04.012",

language = "英语",

volume = "16",

pages = "97--104",

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T1 - Gold nanostars decorated MnO2 nanosheets for magnetic resonance imaging and photothermal erasion of lung cancer cell

AU - Liu, Jing

AU - Cui, Hongbo

AU - Yan, Siyu

AU - Jing, Xunan

AU - Wang, Daquan

AU - Meng, Lingjie

PY - 2018/9

Y1 - 2018/9

N2 - We report a facile fabrication approach for sensitive theranostic nanoprobe - gold nanostars@MnO2 nanosheets, by which gold nanostars were grown on the surface of MnO2 nanosheets. Owing to the ability of gold nanostars to absorb light at near infrared (NIR) wavelength, the nanoprobe showed excellent photothermal conversion effect, while exhibited tumor microenvironment-responsive magnetic resonance imaging property due to the redox property of MnO2 nanosheets. Amazingly, photothermal irradiation experiment showed that the nanoprobe sensitively triggered lung cancer cell death, while produced negligible effect on normal lung epithelial cells. Therefore, these demonstrate that the nanoprobe may have potential application in magnetic resonance imaging-guided photothermal therapy of lung cancer.

AB - We report a facile fabrication approach for sensitive theranostic nanoprobe - gold nanostars@MnO2 nanosheets, by which gold nanostars were grown on the surface of MnO2 nanosheets. Owing to the ability of gold nanostars to absorb light at near infrared (NIR) wavelength, the nanoprobe showed excellent photothermal conversion effect, while exhibited tumor microenvironment-responsive magnetic resonance imaging property due to the redox property of MnO2 nanosheets. Amazingly, photothermal irradiation experiment showed that the nanoprobe sensitively triggered lung cancer cell death, while produced negligible effect on normal lung epithelial cells. Therefore, these demonstrate that the nanoprobe may have potential application in magnetic resonance imaging-guided photothermal therapy of lung cancer.

KW - Gold nanostars

KW - Lung cancer

KW - Magnetic resonance imaging

KW - MnO nanosheets

KW - Photothermal therapy

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U2 - 10.1016/j.mtcomm.2018.04.012

DO - 10.1016/j.mtcomm.2018.04.012

M3 - 文章

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SN - 2352-4928

VL - 16

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JO - Materials Today Communications

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