Abstract
Objective: To investigate the alleles and genotypes frequency of 10 short tandem repeat (STR) loci on the X chromosome (DXS7423, DXS8378, DXS6799, DXS7424, DXS7130, DXS7132, DXS6789, DXS101, DXS6804, DXS7133) of Tibetan individuals living in Xizang Autonomous Region, Southwest China. Methods: The 10 X-chromosomal STR loci were analyzed with PCR, followed by polyacylamide gel electrophoresis and silver staining. Results: Among unrelated Tibetan individuals, the numbers of alleles in the 10 X-STR loci (DXS7423, DXS8378, DXS6799, DXS7424, DXS7130, DXS7132, DXS6789, DXS101, DXS6804, DXS7133) were 5, 5, 5, 9, 7, 7, 11, 9, 5 and 4, respectively. The genotype frequencies in females were in accordance with Hardy-Weinberg equilibrium. Conclusion: The 10 X-chromosomal STRs loci are appropriate for individual identification, for paternity testing involving a female child, and for studies on related disease.
| Original language | English |
|---|---|
| Pages (from-to) | 97-99 |
| Number of pages | 3 |
| Journal | Chinese Journal of Medical Genetics |
| Volume | 23 |
| Issue number | 1 |
| State | Published - 10 Feb 2006 |
Keywords
- Genetic polymorphism
- Short tandem repeat
- X chromosome
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