TY - JOUR
T1 - Genetic polymorphism of six short tandem repeat loci on the X chromosome in a Han race population in China
AU - Feng, Xue
AU - Wang, Yan
AU - Fan, Ying
AU - Yu, Bing
AU - Li, Sheng Bin
PY - 2006/2/10
Y1 - 2006/2/10
N2 - Objective: To investigate the alleles and genotype frequencies of 6 short tandem repeat (STR) loci DXS7130, DXS1214, DXS6799, DXS6804, DXS7424 and DXS7133 on the X chromosome in Chinese Han individuals living in Shaanxi province of Northwest China. Methods: The 6 X-chromosomal STR loci were typed by PCR, denatured polyacylamide gel electrophoresis and silver stain. Results: Among females from Xi' an Han population, the numbers of alleles in the 5 loci (DXS7130, DXS6799, DXS6804, DXS7424 and DXS7133) were detected to be 9, 6, 6, 7, and 7 respectively; the numbers of genotypes were 21, 14, 15, 17 and 12 respectively; and the number of alleles in the DXS1214 was 8. Exact tests demonstrated that genotype frequencies of females had no departure from Hardy-Weinberg equilibrium. Conclusion: The six loci of X-chromosomal STRs are appropriate for individual identification, paternity test involving in female child and for study in related disease.
AB - Objective: To investigate the alleles and genotype frequencies of 6 short tandem repeat (STR) loci DXS7130, DXS1214, DXS6799, DXS6804, DXS7424 and DXS7133 on the X chromosome in Chinese Han individuals living in Shaanxi province of Northwest China. Methods: The 6 X-chromosomal STR loci were typed by PCR, denatured polyacylamide gel electrophoresis and silver stain. Results: Among females from Xi' an Han population, the numbers of alleles in the 5 loci (DXS7130, DXS6799, DXS6804, DXS7424 and DXS7133) were detected to be 9, 6, 6, 7, and 7 respectively; the numbers of genotypes were 21, 14, 15, 17 and 12 respectively; and the number of alleles in the DXS1214 was 8. Exact tests demonstrated that genotype frequencies of females had no departure from Hardy-Weinberg equilibrium. Conclusion: The six loci of X-chromosomal STRs are appropriate for individual identification, paternity test involving in female child and for study in related disease.
KW - Genetic polymorphism
KW - Short tandem repeat
KW - X chromosome
UR - https://www.scopus.com/pages/publications/32644452755
M3 - 文章
C2 - 16456798
AN - SCOPUS:32644452755
SN - 1003-9406
VL - 23
SP - 92
EP - 94
JO - Chinese Journal of Medical Genetics
JF - Chinese Journal of Medical Genetics
IS - 1
ER -