Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population

Xianglong Duan; Xiaolan Li; Huiling Lou; Tingting Geng; Tianbo Jin; Ping Liang; Shanqu Li; Yanbin Long; Chao Chen

doi:10.1007/s13277-013-1242-9

Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population

Xianglong Duan
, Xiaolan Li
, Huiling Lou
, Tingting Geng
, Tianbo Jin
, Ping Liang
, Shanqu Li
, Yanbin Long
, Chao Chen

Health Science Center

Northwest University China
National Engineering Research Center for Miniaturized Detection Systems
Guangzhou First People's Hospital
Air Force Medical University
Tangdu Hospital, Fourth Military Medical University
Shaanxi Province Hospital

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Colorectal cancer (CRC) is a common malignant tumor that is influenced by an interaction between genetic and environmental factors. Currently, the inherited factors of CRC are unclear. Our study selected 19 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with CRC in the Han population. In this Han Chinese case-control study, we genotyped 203 CRC cases and 296 controls using Sequenom MassARRAY technology and analyzed their associations with CRC using χ² tests, SNPStats software, and SHEsis software. Based on χ² tests, PLCE1 -rs2077218, rs11187877 (p = 0.049) and C11orf92-C11orf93-rs3802842 (p = 0.023) correlate with CRC risk. In the genetic model analyses, we found the genotype "CC" of rs3802842 in C11orf92-C11orf93 may significantly increase CRC risk in the recessive model (p = 0.0071), whereas "GT" of rs17109928 in NOC3L may decrease the risk in the over-dominant model (p = 0.0091). Using SHEsis software, we found PLCE1 and NOC3L are strongly linked, and the "GCCATTCTGTC" haplotype may increase the risk of CRC (p = 0.049). We found three genes (PLCE1, C11orf92-C11orf93, and NOC3L) are associated with CRC susceptibility. In combination with previous reports, our results suggest that these genes may be associated with CRC in the Han population.

Original language	English
Pages (from-to)	1813-1817
Number of pages	5
Journal	Tumor Biology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s13277-013-1242-9
State	Published - Mar 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Case-control study
Colorectal cancer (CRC)
Haplotype
Tag single nucleotide polymorphism (tSNP)

Access to Document

10.1007/s13277-013-1242-9

Cite this

@article{ffabbc9a7aff422e86efa34e3344bb83,

title = "Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population",

abstract = "Colorectal cancer (CRC) is a common malignant tumor that is influenced by an interaction between genetic and environmental factors. Currently, the inherited factors of CRC are unclear. Our study selected 19 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with CRC in the Han population. In this Han Chinese case-control study, we genotyped 203 CRC cases and 296 controls using Sequenom MassARRAY technology and analyzed their associations with CRC using χ2 tests, SNPStats software, and SHEsis software. Based on χ2 tests, PLCE1 -rs2077218, rs11187877 (p = 0.049) and C11orf92-C11orf93-rs3802842 (p = 0.023) correlate with CRC risk. In the genetic model analyses, we found the genotype {"}CC{"} of rs3802842 in C11orf92-C11orf93 may significantly increase CRC risk in the recessive model (p = 0.0071), whereas {"}GT{"} of rs17109928 in NOC3L may decrease the risk in the over-dominant model (p = 0.0091). Using SHEsis software, we found PLCE1 and NOC3L are strongly linked, and the {"}GCCATTCTGTC{"} haplotype may increase the risk of CRC (p = 0.049). We found three genes (PLCE1, C11orf92-C11orf93, and NOC3L) are associated with CRC susceptibility. In combination with previous reports, our results suggest that these genes may be associated with CRC in the Han population.",

keywords = "Case-control study, Colorectal cancer (CRC), Haplotype, Tag single nucleotide polymorphism (tSNP)",

author = "Xianglong Duan and Xiaolan Li and Huiling Lou and Tingting Geng and Tianbo Jin and Ping Liang and Shanqu Li and Yanbin Long and Chao Chen",

year = "2014",

month = mar,

doi = "10.1007/s13277-013-1242-9",

language = "英语",

volume = "35",

pages = "1813--1817",

journal = "Tumor Biology",

issn = "1010-4283",

publisher = "SAGE Publications Ltd",

number = "3",

}

TY - JOUR

T1 - Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population

AU - Duan, Xianglong

AU - Li, Xiaolan

AU - Lou, Huiling

AU - Geng, Tingting

AU - Jin, Tianbo

AU - Liang, Ping

AU - Li, Shanqu

AU - Long, Yanbin

AU - Chen, Chao

PY - 2014/3

Y1 - 2014/3

N2 - Colorectal cancer (CRC) is a common malignant tumor that is influenced by an interaction between genetic and environmental factors. Currently, the inherited factors of CRC are unclear. Our study selected 19 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with CRC in the Han population. In this Han Chinese case-control study, we genotyped 203 CRC cases and 296 controls using Sequenom MassARRAY technology and analyzed their associations with CRC using χ2 tests, SNPStats software, and SHEsis software. Based on χ2 tests, PLCE1 -rs2077218, rs11187877 (p = 0.049) and C11orf92-C11orf93-rs3802842 (p = 0.023) correlate with CRC risk. In the genetic model analyses, we found the genotype "CC" of rs3802842 in C11orf92-C11orf93 may significantly increase CRC risk in the recessive model (p = 0.0071), whereas "GT" of rs17109928 in NOC3L may decrease the risk in the over-dominant model (p = 0.0091). Using SHEsis software, we found PLCE1 and NOC3L are strongly linked, and the "GCCATTCTGTC" haplotype may increase the risk of CRC (p = 0.049). We found three genes (PLCE1, C11orf92-C11orf93, and NOC3L) are associated with CRC susceptibility. In combination with previous reports, our results suggest that these genes may be associated with CRC in the Han population.

AB - Colorectal cancer (CRC) is a common malignant tumor that is influenced by an interaction between genetic and environmental factors. Currently, the inherited factors of CRC are unclear. Our study selected 19 tag single nucleotide polymorphisms (tSNPs) to investigate whether they were associated with CRC in the Han population. In this Han Chinese case-control study, we genotyped 203 CRC cases and 296 controls using Sequenom MassARRAY technology and analyzed their associations with CRC using χ2 tests, SNPStats software, and SHEsis software. Based on χ2 tests, PLCE1 -rs2077218, rs11187877 (p = 0.049) and C11orf92-C11orf93-rs3802842 (p = 0.023) correlate with CRC risk. In the genetic model analyses, we found the genotype "CC" of rs3802842 in C11orf92-C11orf93 may significantly increase CRC risk in the recessive model (p = 0.0071), whereas "GT" of rs17109928 in NOC3L may decrease the risk in the over-dominant model (p = 0.0091). Using SHEsis software, we found PLCE1 and NOC3L are strongly linked, and the "GCCATTCTGTC" haplotype may increase the risk of CRC (p = 0.049). We found three genes (PLCE1, C11orf92-C11orf93, and NOC3L) are associated with CRC susceptibility. In combination with previous reports, our results suggest that these genes may be associated with CRC in the Han population.

KW - Case-control study

KW - Colorectal cancer (CRC)

KW - Haplotype

KW - Tag single nucleotide polymorphism (tSNP)

UR - https://www.scopus.com/pages/publications/84899049703

U2 - 10.1007/s13277-013-1242-9

DO - 10.1007/s13277-013-1242-9

M3 - 文章

C2 - 24146276

AN - SCOPUS:84899049703

SN - 1010-4283

VL - 35

SP - 1813

EP - 1817

JO - Tumor Biology

JF - Tumor Biology

IS - 3

ER -

Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population

Abstract

UN SDGs

Keywords

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