TY - JOUR
T1 - Genetic architecture and selection of Chinese cattle revealed by whole genome resequencing
AU - Mei, Chugang
AU - Wang, Hongcheng
AU - Liao, Qijun
AU - Wang, Lizhong
AU - Cheng, Gong
AU - Wang, Hongbao
AU - Zhao, Chunping
AU - Zhao, Shancen
AU - Song, Jiuzhou
AU - Guang, Xuanmin
AU - Liu, George E.
AU - Li, Anning
AU - Wu, Xueli
AU - Wang, Chongzhi
AU - Fang, Xiaodong
AU - Zhao, Xin
AU - Smith, Stephen B.
AU - Yang, Wucai
AU - Tian, Wanqiang
AU - Gui, Linsheng
AU - Zhang, Yingying
AU - Hill, Rodney A.
AU - Jiang, Zhongliang
AU - Xin, Yaping
AU - Jia, Cunling
AU - Sun, Xiuzhu
AU - Wang, Shuhui
AU - Yang, Huanming
AU - Wang, Jian
AU - Zhu, Wenjuan
AU - Zan, Linsen
N1 - Publisher Copyright:
© The Author 2017.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - The bovine genetic resources in China are diverse, but their value and potential are yet to be discovered. To determine the genetic diversity and population structure of Chinese cattle, we analyzed the whole genomes of 46 cattle from six phenotypically and geographically representative Chinese cattle breeds, together with 18 Red Angus cattle genomes, 11 Japanese black cattle genomes and taurine and indicine genomes available from previous studies. Our results showed that Chinese cattle originated from hybridization between Bos taurus and Bos indicus. Moreover, we found that the level of genetic variation in Chinese cattle depends upon the degree of indicine content. We also discovered many potential selective sweep regions associated with domestication related to breed-specific characteristics, with selective sweep regions including genes associated with coat color (ERCC2, MC1R, ZBTB17, and MAP2K1), dairy traits (NCAPG, MAPK7, FST, ITFG1, SETMAR, PAG1, CSN3, and RPL37A), and meat production/quality traits (such as BBS2, R3HDM1, IGFBP2, IGFBP5, MYH9, MYH4, and MC5R). These findings substantially expand the catalogue of genetic variants in cattle and reveal new insights into the evolutionary history and domestication traits of Chinese cattle.
AB - The bovine genetic resources in China are diverse, but their value and potential are yet to be discovered. To determine the genetic diversity and population structure of Chinese cattle, we analyzed the whole genomes of 46 cattle from six phenotypically and geographically representative Chinese cattle breeds, together with 18 Red Angus cattle genomes, 11 Japanese black cattle genomes and taurine and indicine genomes available from previous studies. Our results showed that Chinese cattle originated from hybridization between Bos taurus and Bos indicus. Moreover, we found that the level of genetic variation in Chinese cattle depends upon the degree of indicine content. We also discovered many potential selective sweep regions associated with domestication related to breed-specific characteristics, with selective sweep regions including genes associated with coat color (ERCC2, MC1R, ZBTB17, and MAP2K1), dairy traits (NCAPG, MAPK7, FST, ITFG1, SETMAR, PAG1, CSN3, and RPL37A), and meat production/quality traits (such as BBS2, R3HDM1, IGFBP2, IGFBP5, MYH9, MYH4, and MC5R). These findings substantially expand the catalogue of genetic variants in cattle and reveal new insights into the evolutionary history and domestication traits of Chinese cattle.
KW - Admixture
KW - Chinese cattle
KW - Indicine components
KW - Selection
KW - Whole genome sequencing
UR - https://www.scopus.com/pages/publications/85045949744
U2 - 10.1093/molbev/msx322
DO - 10.1093/molbev/msx322
M3 - 文章
C2 - 29294071
AN - SCOPUS:85045949744
SN - 0737-4038
VL - 35
SP - 688
EP - 699
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
IS - 3
ER -