Genescan for STR analysis and genetic distribution in a population sample from Han, China

Genetic distributions for nine STR loci and Amelogenin locus were determined in a Chinese Han population based on DNA sequencing. The databanks in Chinese Population were generated by using Genescan, genotype and genetic distribution analysis. Allele frequentcy distribution was determined for 10 loci, such as D3S1358, VWA, FGA, Amelogenin, THO1, TPOX, CSF1PO, D5S818, D13S317 and D7S820. The results show significant differences between ethnic groups (African-American, US-Caucasian and Chinese Han) in the pattern of distribution as well as in the related frequency of the most common alleles of their STR loci. The probabilities of identity values for the population described in this section are 2.79 × 10^-10 (U.S-Caucasian), 1.23 × 10^-10 (African-American) and 0.5 × 10^-10 (Chinese Han). The results show the probability of Paternity Exclusion (PPE) values of 0.9998 (Chinese Han), 0.9996 (African-American) and 0.9994 (U.S-Caucasian). These results suggested that the nine STR loci and the Amelogenin locus are very useful for human identification, such as analyzing forensis casework, establishing DNA databanks, processing paternity test, evaluation linkage genetics, studying gene natural resources and monitoring bone marrow transplants.