Gender difference regarding schizandrin pharmacokinetics in rats

Mei Juan Xu; Guang Ji Wang; Hai Tang Xie; Hao Li; Qing Huang; Rui Wang; Yuan Wei Jia; Tian Lv

doi:10.1007/BF03191022

Gender difference regarding schizandrin pharmacokinetics in rats

Mei Juan Xu
, Guang Ji Wang
, Hai Tang Xie
, Hao Li
, Qing Huang
, Rui Wang
, Yuan Wei Jia
, Tian Lv

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The difference in the pharmacokinetics of schizandrin (SZ) in male and female rats was studied. SZ concentrations in the plasma were determined after the intragastric (i.g) administration of 10 mg/kg and the intravenous (i.v) administration of 5 mg/kg in male and female rats, respectively. It was found that the plasma concentrations of SZ in female rats were significantly higher than those in male rats. Drug absolute bioavailability, based on the area under curve (AUC_0-tn), in female rats was roughly 20 times of that in male rats. The terminate half-life (T_1/2) in male rats was shorter than that in female rats. These results demonstrate the existence of marked gender differences for SZ in rats.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	33
Issue number	2
DOIs	https://doi.org/10.1007/BF03191022
State	Published - 2008
Externally published	Yes

Keywords

Gender difference
Pharmacokinetics
Schizandrin

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10.1007/BF03191022

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title = "Gender difference regarding schizandrin pharmacokinetics in rats",

abstract = "The difference in the pharmacokinetics of schizandrin (SZ) in male and female rats was studied. SZ concentrations in the plasma were determined after the intragastric (i.g) administration of 10 mg/kg and the intravenous (i.v) administration of 5 mg/kg in male and female rats, respectively. It was found that the plasma concentrations of SZ in female rats were significantly higher than those in male rats. Drug absolute bioavailability, based on the area under curve (AUC0-tn), in female rats was roughly 20 times of that in male rats. The terminate half-life (T1/2) in male rats was shorter than that in female rats. These results demonstrate the existence of marked gender differences for SZ in rats.",

keywords = "Gender difference, Pharmacokinetics, Schizandrin",

author = "Xu, \{Mei Juan\} and Wang, \{Guang Ji\} and Xie, \{Hai Tang\} and Hao Li and Qing Huang and Rui Wang and Jia, \{Yuan Wei\} and Tian Lv",

year = "2008",

doi = "10.1007/BF03191022",

language = "英语",

volume = "33",

pages = "65--68",

journal = "European Journal of Drug Metabolism and Pharmacokinetics",

issn = "0378-7966",

publisher = "Adis",

number = "2",

}

TY - JOUR

T1 - Gender difference regarding schizandrin pharmacokinetics in rats

AU - Xu, Mei Juan

AU - Wang, Guang Ji

AU - Xie, Hai Tang

AU - Li, Hao

AU - Huang, Qing

AU - Wang, Rui

AU - Jia, Yuan Wei

AU - Lv, Tian

PY - 2008

Y1 - 2008

N2 - The difference in the pharmacokinetics of schizandrin (SZ) in male and female rats was studied. SZ concentrations in the plasma were determined after the intragastric (i.g) administration of 10 mg/kg and the intravenous (i.v) administration of 5 mg/kg in male and female rats, respectively. It was found that the plasma concentrations of SZ in female rats were significantly higher than those in male rats. Drug absolute bioavailability, based on the area under curve (AUC0-tn), in female rats was roughly 20 times of that in male rats. The terminate half-life (T1/2) in male rats was shorter than that in female rats. These results demonstrate the existence of marked gender differences for SZ in rats.

AB - The difference in the pharmacokinetics of schizandrin (SZ) in male and female rats was studied. SZ concentrations in the plasma were determined after the intragastric (i.g) administration of 10 mg/kg and the intravenous (i.v) administration of 5 mg/kg in male and female rats, respectively. It was found that the plasma concentrations of SZ in female rats were significantly higher than those in male rats. Drug absolute bioavailability, based on the area under curve (AUC0-tn), in female rats was roughly 20 times of that in male rats. The terminate half-life (T1/2) in male rats was shorter than that in female rats. These results demonstrate the existence of marked gender differences for SZ in rats.

KW - Gender difference

KW - Pharmacokinetics

KW - Schizandrin

UR - https://www.scopus.com/pages/publications/51049105675

U2 - 10.1007/BF03191022

DO - 10.1007/BF03191022

M3 - 文章

C2 - 18777941

AN - SCOPUS:51049105675

SN - 0378-7966

VL - 33

SP - 65

EP - 68

JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

IS - 2

ER -

Gender difference regarding schizandrin pharmacokinetics in rats

Abstract

Keywords

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