GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer

Xianglong Duan; Liang Shan; Shuai Shi; Boyu Xu; Xin Chen; Jinqin Di; Bopeng Chen; Xiaoqing Li; Sida Liu; Yuhe Wang; Wei Yang

doi:10.2217/fon-2021-0973

GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer

Xianglong Duan
, Liang Shan
, Shuai Shi
, Boyu Xu
, Xin Chen
, Jinqin Di
, Bopeng Chen
, Xiaoqing Li
, Sida Liu
, Yuhe Wang
, Wei Yang

Health Science Center

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Aim: This study was designed to evaluate the contribution of GBAP1 variants to gastric cancer (GC) risk in a Chinese Han population. Methods: The genotypes of GBAP1 polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs. Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50 × 10-07), rs1057941 (OR = 0.48, p = 1.19 × 10-08) and rs2990220 (OR = 0.46, p = 7.34 × 10-09) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. Conclusion: This research suggested that GBAP1 polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.

Original language	English
Pages (from-to)	1861-1872
Number of pages	12
Journal	Future Oncology
Volume	18
Issue number	15
DOIs	https://doi.org/10.2217/fon-2021-0973
State	Published - May 2022

Keywords

"yes">GBAP1 variants
clinical phenotypes
gastric cancer
lifestyle
predisposition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fon-2021-0973

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@article{8de070f5b1e84b57b18e0b89f4f9741b,

title = "GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer",

abstract = "Aim: This study was designed to evaluate the contribution of GBAP1 variants to gastric cancer (GC) risk in a Chinese Han population. Methods: The genotypes of GBAP1 polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95\% CIs. Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50 × 10-07), rs1057941 (OR = 0.48, p = 1.19 × 10-08) and rs2990220 (OR = 0.46, p = 7.34 × 10-09) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. Conclusion: This research suggested that GBAP1 polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.",

keywords = "{"}yes{"}>GBAP1 variants, clinical phenotypes, gastric cancer, lifestyle, predisposition",

author = "Xianglong Duan and Liang Shan and Shuai Shi and Boyu Xu and Xin Chen and Jinqin Di and Bopeng Chen and Xiaoqing Li and Sida Liu and Yuhe Wang and Wei Yang",

note = "Publisher Copyright: {\textcopyright} 2022 Xiaoqing Li.",

year = "2022",

month = may,

doi = "10.2217/fon-2021-0973",

language = "英语",

volume = "18",

pages = "1861--1872",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Taylor and Francis Ltd.",

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}

TY - JOUR

T1 - GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer

AU - Duan, Xianglong

AU - Shan, Liang

AU - Shi, Shuai

AU - Xu, Boyu

AU - Chen, Xin

AU - Di, Jinqin

AU - Chen, Bopeng

AU - Li, Xiaoqing

AU - Liu, Sida

AU - Wang, Yuhe

AU - Yang, Wei

PY - 2022/5

Y1 - 2022/5

N2 - Aim: This study was designed to evaluate the contribution of GBAP1 variants to gastric cancer (GC) risk in a Chinese Han population. Methods: The genotypes of GBAP1 polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs. Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50 × 10-07), rs1057941 (OR = 0.48, p = 1.19 × 10-08) and rs2990220 (OR = 0.46, p = 7.34 × 10-09) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. Conclusion: This research suggested that GBAP1 polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.

AB - Aim: This study was designed to evaluate the contribution of GBAP1 variants to gastric cancer (GC) risk in a Chinese Han population. Methods: The genotypes of GBAP1 polymorphisms were detected using the Agena MassARRAY platform. Logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs. Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50 × 10-07), rs1057941 (OR = 0.48, p = 1.19 × 10-08) and rs2990220 (OR = 0.46, p = 7.34 × 10-09) contribute to reduced GC risk, especially gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking. Conclusion: This research suggested that GBAP1 polymorphisms might provide a protective effect against GC occurrence in a Chinese Han population.

KW - "yes">GBAP1 variants

KW - clinical phenotypes

KW - gastric cancer

KW - lifestyle

KW - predisposition

UR - https://www.scopus.com/pages/publications/85128749003

U2 - 10.2217/fon-2021-0973

DO - 10.2217/fon-2021-0973

M3 - 文章

C2 - 35156841

AN - SCOPUS:85128749003

SN - 1479-6694

VL - 18

SP - 1861

EP - 1872

JO - Future Oncology

JF - Future Oncology

IS - 15

ER -

GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to reduced risk of gastric cancer

Abstract

Keywords

UN SDGs

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