FRS2α-dependent cell fate transition during endocardial cushion morphogenesis

Dongying Chen; Xiaolong Zhu; Natalie Kofler; Yidong Wang; Bin Zhou; Michael Simons

doi:10.1016/j.ydbio.2019.10.022

FRS2α-dependent cell fate transition during endocardial cushion morphogenesis

Dongying Chen
, Xiaolong Zhu
, Natalie Kofler
, Yidong Wang
, Bin Zhou
, Michael Simons

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

FRS2α controls a two-phase cell fate transition of endocardial lineage during valve morphogenesis, from endocardial cells to cushion mesenchymal cells (endothelial-to-mesenchymal transition) and then to valve interstitial cells (terminal differentiation).

Original language	English
Pages (from-to)	88-97
Number of pages	10
Journal	Developmental Biology
Volume	458
Issue number	1
DOIs	https://doi.org/10.1016/j.ydbio.2019.10.022
State	Published - 1 Feb 2020
Externally published	Yes

Keywords

Cardiovascular development
Cell fate
EndMT
Endocardial cushion
Endothelial-to-mesenchymal transition
Valvulogenesis

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10.1016/j.ydbio.2019.10.022

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title = "FRS2α-dependent cell fate transition during endocardial cushion morphogenesis",

abstract = "FRS2α controls a two-phase cell fate transition of endocardial lineage during valve morphogenesis, from endocardial cells to cushion mesenchymal cells (endothelial-to-mesenchymal transition) and then to valve interstitial cells (terminal differentiation).",

keywords = "Cardiovascular development, Cell fate, EndMT, Endocardial cushion, Endothelial-to-mesenchymal transition, Valvulogenesis",

author = "Dongying Chen and Xiaolong Zhu and Natalie Kofler and Yidong Wang and Bin Zhou and Michael Simons",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2020",

month = feb,

day = "1",

doi = "10.1016/j.ydbio.2019.10.022",

language = "英语",

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T1 - FRS2α-dependent cell fate transition during endocardial cushion morphogenesis

AU - Chen, Dongying

AU - Zhu, Xiaolong

AU - Kofler, Natalie

AU - Wang, Yidong

AU - Zhou, Bin

AU - Simons, Michael

PY - 2020/2/1

Y1 - 2020/2/1

N2 - FRS2α controls a two-phase cell fate transition of endocardial lineage during valve morphogenesis, from endocardial cells to cushion mesenchymal cells (endothelial-to-mesenchymal transition) and then to valve interstitial cells (terminal differentiation).

AB - FRS2α controls a two-phase cell fate transition of endocardial lineage during valve morphogenesis, from endocardial cells to cushion mesenchymal cells (endothelial-to-mesenchymal transition) and then to valve interstitial cells (terminal differentiation).

KW - Cardiovascular development

KW - Cell fate

KW - EndMT

KW - Endocardial cushion

KW - Endothelial-to-mesenchymal transition

KW - Valvulogenesis

UR - https://www.scopus.com/pages/publications/85074176807

U2 - 10.1016/j.ydbio.2019.10.022

DO - 10.1016/j.ydbio.2019.10.022

M3 - 文章

C2 - 31669335

AN - SCOPUS:85074176807

SN - 0012-1606

VL - 458

SP - 88

EP - 97

JO - Developmental Biology

JF - Developmental Biology

IS - 1

ER -

FRS2α-dependent cell fate transition during endocardial cushion morphogenesis

Abstract

Keywords

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