Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese

Guang Yang; Ya Jun Deng; Chun Xia Yan; Dong Ying Wu; Song Nian Hu; Bo Feng Zhu; Sheng Bin Li; Xiu Qing Zhang; Yao Liu

Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese

Guang Yang
, Ya Jun Deng
, Chun Xia Yan
, Dong Ying Wu
, Song Nian Hu
, Bo Feng Zhu
, Sheng Bin Li
, Xiu Qing Zhang
, Yao Liu

Health Science Center

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese. Method: Polymerase chain reaction sequence-based typing (PCR-SBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese. Results: A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%), B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%). Conclusion: The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.

Original language	English
Pages (from-to)	240-243
Number of pages	4
Journal	Acta Academiae Medicinae Sinicae
Volume	28
Issue number	2
State	Published - Apr 2006

Keywords

Ankylosing spondylitis
Frequency
Human leukocyte antigen-B27
Subtype

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{aa2b8a62396e43e8a1457be284f7150a,

title = "Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese",

abstract = "Objective: To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese. Method: Polymerase chain reaction sequence-based typing (PCR-SBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese. Results: A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77\%), B * 2705 (23.08\%), B * 2707 (19.23\%), B * 2711 (7.69\%), B * 2712 (7.69\%), B * 2701 (3.85\%), B * 2713 (3.85\%) and B * 2721 (3.85\%). Conclusion: The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.",

keywords = "Ankylosing spondylitis, Frequency, Human leukocyte antigen-B27, Subtype",

author = "Guang Yang and Deng, \{Ya Jun\} and Yan, \{Chun Xia\} and Wu, \{Dong Ying\} and Hu, \{Song Nian\} and Zhu, \{Bo Feng\} and Li, \{Sheng Bin\} and Zhang, \{Xiu Qing\} and Yao Liu",

year = "2006",

month = apr,

language = "英语",

volume = "28",

pages = "240--243",

journal = "Acta Academiae Medicinae Sinicae",

issn = "1000-503X",

publisher = "Chinese Academy of Medical Sciences",

number = "2",

}

TY - JOUR

T1 - Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese

AU - Yang, Guang

AU - Deng, Ya Jun

AU - Yan, Chun Xia

AU - Wu, Dong Ying

AU - Hu, Song Nian

AU - Zhu, Bo Feng

AU - Li, Sheng Bin

AU - Zhang, Xiu Qing

AU - Liu, Yao

PY - 2006/4

Y1 - 2006/4

N2 - Objective: To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese. Method: Polymerase chain reaction sequence-based typing (PCR-SBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese. Results: A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%), B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%). Conclusion: The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.

AB - Objective: To investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese. Method: Polymerase chain reaction sequence-based typing (PCR-SBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese. Results: A total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%), B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%). Conclusion: The data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.

KW - Ankylosing spondylitis

KW - Frequency

KW - Human leukocyte antigen-B27

KW - Subtype

UR - https://www.scopus.com/pages/publications/33744802221

M3 - 文章

C2 - 16733912

AN - SCOPUS:33744802221

SN - 1000-503X

VL - 28

SP - 240

EP - 243

JO - Acta Academiae Medicinae Sinicae

JF - Acta Academiae Medicinae Sinicae

IS - 2

ER -

Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese

Abstract

Keywords

UN SDGs

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