FOXO1: Another avenue for treating digestive malignancy?

Feiyu Shi; Tian Li; Zhi Liu; Kai Qu; Chengxin Shi; Yaguang Li; Qian Qin; Liang Cheng; Xin Jin; Tianyu Yu; Wencheng Di; Jianwen Que; Hongping Xia; Junjun She

doi:10.1016/j.semcancer.2017.09.009

FOXO1: Another avenue for treating digestive malignancy?

Feiyu Shi
, Tian Li
, Zhi Liu
, Kai Qu
, Chengxin Shi
, Yaguang Li
, Qian Qin
, Liang Cheng
, Xin Jin
, Tianyu Yu
, Wencheng Di
, Jianwen Que
, Hongping Xia
, Junjun She

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.

Original language	English
Pages (from-to)	124-131
Number of pages	8
Journal	Seminars in Cancer Biology
Volume	50
DOIs	https://doi.org/10.1016/j.semcancer.2017.09.009
State	Published - Jun 2018
Externally published	Yes

Keywords

Akt
Digestive malignancy
Forkhead box O1
Hepatocellular carcinoma
microRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2017.09.009

Cite this

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title = "FOXO1: Another avenue for treating digestive malignancy?",

abstract = "Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.",

keywords = "Akt, Digestive malignancy, Forkhead box O1, Hepatocellular carcinoma, microRNA",

author = "Feiyu Shi and Tian Li and Zhi Liu and Kai Qu and Chengxin Shi and Yaguang Li and Qian Qin and Liang Cheng and Xin Jin and Tianyu Yu and Wencheng Di and Jianwen Que and Hongping Xia and Junjun She",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2018",

month = jun,

doi = "10.1016/j.semcancer.2017.09.009",

language = "英语",

volume = "50",

pages = "124--131",

journal = "Seminars in Cancer Biology",

issn = "1044-579X",

publisher = "Academic Press",

}

TY - JOUR

T1 - FOXO1

T2 - Another avenue for treating digestive malignancy?

AU - Shi, Feiyu

AU - Li, Tian

AU - Liu, Zhi

AU - Qu, Kai

AU - Shi, Chengxin

AU - Li, Yaguang

AU - Qin, Qian

AU - Cheng, Liang

AU - Jin, Xin

AU - Yu, Tianyu

AU - Di, Wencheng

AU - Que, Jianwen

AU - Xia, Hongping

AU - She, Junjun

PY - 2018/6

Y1 - 2018/6

N2 - Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.

AB - Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.

KW - Akt

KW - Digestive malignancy

KW - Forkhead box O1

KW - Hepatocellular carcinoma

KW - microRNA

UR - https://www.scopus.com/pages/publications/85030474464

U2 - 10.1016/j.semcancer.2017.09.009

DO - 10.1016/j.semcancer.2017.09.009

M3 - 文献综述

C2 - 28965871

AN - SCOPUS:85030474464

SN - 1044-579X

VL - 50

SP - 124

EP - 131

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

FOXO1: Another avenue for treating digestive malignancy?

Abstract

Keywords

UN SDGs

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