Fourier transform infrared microspectroscopy of rat kidney with regard to fatal hyperthermia

Zhi Jun Wang; Shan Shan Shen; Kai Fei Deng; Zhi Qiang Qin; Ping Huang; Zhen Yuan Wang

doi:10.3969/j.issn.1004-5619.2015.04.001

Fourier transform infrared microspectroscopy of rat kidney with regard to fatal hyperthermia

Zhi Jun Wang
, Shan Shan Shen
, Kai Fei Deng
, Zhi Qiang Qin
, Ping Huang
, Zhen Yuan Wang

Health Science Center

Xi'an Jiaotong University
Ministry of Justice, China
Nanshi District of Baoding Public Security Bureau

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To observe the chemical groups changing in rat kidney with regard to fatal hyperthermia by Fourier transform infrared microspectroscopy (FTIR-MSP) and to provide a new method to diagnose fatal hyperthermia. Methods: Rats were sacrificed by hyperthermia, brainstem injury, massive hemorrhage and asphyxiation and divided into groups. The renal samples were dissected immediately after death. The data of infrared spectroscopy in glomerulus were measured by FTIR-MSP. Results: The absorbances of 3 290, 3 070, 2 850, 1540 and 1396 cm^-1 significantly increased (P<0.05), and the ratios of A₁₆₅₀/A₃₂₉₀ and A₁₆₅₀/A₁₅₄₀ significantly decreased (P<0.05) in group of hyperthermia. Conclusion: FTIR-MSP can analyze the changes of chemical groups of kidney as an auxiliary diagnosis for discriminating hyperthermia with other causes of death.

Original language	English
Pages (from-to)	257-261
Number of pages	5
Journal	Journal of Forensic Medicine
Volume	31
Issue number	4
DOIs	https://doi.org/10.3969/j.issn.1004-5619.2015.04.001
State	Published - 25 Aug 2015

Keywords

Cause of death
Forensic pathology
Hyperthermia
Kidney
Rats
Spectroscopy, Fourier transform infrared

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10.3969/j.issn.1004-5619.2015.04.001

Cite this

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title = "Fourier transform infrared microspectroscopy of rat kidney with regard to fatal hyperthermia",

abstract = "Objective: To observe the chemical groups changing in rat kidney with regard to fatal hyperthermia by Fourier transform infrared microspectroscopy (FTIR-MSP) and to provide a new method to diagnose fatal hyperthermia. Methods: Rats were sacrificed by hyperthermia, brainstem injury, massive hemorrhage and asphyxiation and divided into groups. The renal samples were dissected immediately after death. The data of infrared spectroscopy in glomerulus were measured by FTIR-MSP. Results: The absorbances of 3 290, 3 070, 2 850, 1540 and 1396 cm-1 significantly increased (P<0.05), and the ratios of A1650/A3290 and A1650/A1540 significantly decreased (P<0.05) in group of hyperthermia. Conclusion: FTIR-MSP can analyze the changes of chemical groups of kidney as an auxiliary diagnosis for discriminating hyperthermia with other causes of death.",

keywords = "Cause of death, Forensic pathology, Hyperthermia, Kidney, Rats, Spectroscopy, Fourier transform infrared",

author = "Wang, \{Zhi Jun\} and Shen, \{Shan Shan\} and Deng, \{Kai Fei\} and Qin, \{Zhi Qiang\} and Ping Huang and Wang, \{Zhen Yuan\}",

note = "Publisher Copyright: {\textcopyright} 2015 by the Editorial Department of Journal of Forensic Medicine.",

year = "2015",

month = aug,

day = "25",

doi = "10.3969/j.issn.1004-5619.2015.04.001",

language = "英语",

volume = "31",

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TY - JOUR

T1 - Fourier transform infrared microspectroscopy of rat kidney with regard to fatal hyperthermia

AU - Wang, Zhi Jun

AU - Shen, Shan Shan

AU - Deng, Kai Fei

AU - Qin, Zhi Qiang

AU - Huang, Ping

AU - Wang, Zhen Yuan

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Objective: To observe the chemical groups changing in rat kidney with regard to fatal hyperthermia by Fourier transform infrared microspectroscopy (FTIR-MSP) and to provide a new method to diagnose fatal hyperthermia. Methods: Rats were sacrificed by hyperthermia, brainstem injury, massive hemorrhage and asphyxiation and divided into groups. The renal samples were dissected immediately after death. The data of infrared spectroscopy in glomerulus were measured by FTIR-MSP. Results: The absorbances of 3 290, 3 070, 2 850, 1540 and 1396 cm-1 significantly increased (P<0.05), and the ratios of A1650/A3290 and A1650/A1540 significantly decreased (P<0.05) in group of hyperthermia. Conclusion: FTIR-MSP can analyze the changes of chemical groups of kidney as an auxiliary diagnosis for discriminating hyperthermia with other causes of death.

AB - Objective: To observe the chemical groups changing in rat kidney with regard to fatal hyperthermia by Fourier transform infrared microspectroscopy (FTIR-MSP) and to provide a new method to diagnose fatal hyperthermia. Methods: Rats were sacrificed by hyperthermia, brainstem injury, massive hemorrhage and asphyxiation and divided into groups. The renal samples were dissected immediately after death. The data of infrared spectroscopy in glomerulus were measured by FTIR-MSP. Results: The absorbances of 3 290, 3 070, 2 850, 1540 and 1396 cm-1 significantly increased (P<0.05), and the ratios of A1650/A3290 and A1650/A1540 significantly decreased (P<0.05) in group of hyperthermia. Conclusion: FTIR-MSP can analyze the changes of chemical groups of kidney as an auxiliary diagnosis for discriminating hyperthermia with other causes of death.

KW - Cause of death

KW - Forensic pathology

KW - Hyperthermia

KW - Kidney

KW - Rats

KW - Spectroscopy, Fourier transform infrared

UR - https://www.scopus.com/pages/publications/84941797819

U2 - 10.3969/j.issn.1004-5619.2015.04.001

DO - 10.3969/j.issn.1004-5619.2015.04.001

M3 - 文章

C2 - 26665876

AN - SCOPUS:84941797819

SN - 1004-5619

VL - 31

SP - 257

EP - 261

JO - Journal of Forensic Medicine

JF - Journal of Forensic Medicine

IS - 4

ER -

Fourier transform infrared microspectroscopy of rat kidney with regard to fatal hyperthermia

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