TY - JOUR
T1 - Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk
T2 - Evidence from 13,716 cancer patients and 15,590 cancer-free controls
AU - Liu, Di
AU - Zheng, Yi
AU - Wang, Meng
AU - Deng, Yujiao
AU - Lin, Shuai
AU - Zhou, Linghui
AU - Yang, Pengtao
AU - Dai, Cong
AU - Xu, Peng
AU - Hao, Qian
AU - Song, Dingli
AU - Kang, Huafeng
AU - Dai, Zhijun
N1 - Publisher Copyright:
© Liu et al.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (P < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population (P < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people (P < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population.
AB - Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (P < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population (P < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people (P < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population.
KW - BRIP1
KW - Cancer risk
KW - Meta-analysis
KW - Polymorphism
UR - https://www.scopus.com/pages/publications/85042726507
U2 - 10.18632/aging.101388
DO - 10.18632/aging.101388
M3 - 文章
C2 - 29466248
AN - SCOPUS:85042726507
SN - 1945-4589
VL - 10
SP - 266
EP - 277
JO - Aging
JF - Aging
IS - 2
ER -
