Folate-conjugated PEG on single walled carbon nanotubes for targeting delivery of doxorubicin to cancer cells

Lvye Niu; Lingjie Meng; Qinghua Lu

doi:10.1002/mabi.201200475

Folate-conjugated PEG on single walled carbon nanotubes for targeting delivery of doxorubicin to cancer cells

Lvye Niu
, Lingjie Meng
, Qinghua Lu

Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

A highly effective drug carrier is constructed by coating folic acid-terminated poly(ethylene glycol) (PEG-FA) on single walled carbon nanotubes (SWNTs) in a facile non-covalent method. The anti-cancer drug, doxorubicin (DOX), is further loaded on the surface of SWNTs at a very high loading efficiency, 149.3±4.1%. The drug system (DOX/PEG-FA/SWNTs) exhibits excellent stability under neutral pH conditions such as serum, but dramatically releases DOX at reduced pH typical of the tumour environment and intracellular lysosomes and endosomes. With the help of FA, DOX/PEG-FA/SWNTs tend to selectively attach onto cancer cells and enter the lysosomes or endosomes by clathrin-mediated endocytosis. This can greatly improve the pharmaceutical efficiency and reduce potential side effects.

Original language	English
Pages (from-to)	735-744
Number of pages	10
Journal	Macromolecular Bioscience
Volume	13
Issue number	6
DOIs	https://doi.org/10.1002/mabi.201200475
State	Published - Jun 2013
Externally published	Yes

Keywords

Biocompatibility
Drug delivery system
Folic acid (FA)
Poly(ethylene glycol) (PEG)
Single walled carbon nanotubes (SWNTs)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mabi.201200475

Cite this

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title = "Folate-conjugated PEG on single walled carbon nanotubes for targeting delivery of doxorubicin to cancer cells",

abstract = "A highly effective drug carrier is constructed by coating folic acid-terminated poly(ethylene glycol) (PEG-FA) on single walled carbon nanotubes (SWNTs) in a facile non-covalent method. The anti-cancer drug, doxorubicin (DOX), is further loaded on the surface of SWNTs at a very high loading efficiency, 149.3±4.1\%. The drug system (DOX/PEG-FA/SWNTs) exhibits excellent stability under neutral pH conditions such as serum, but dramatically releases DOX at reduced pH typical of the tumour environment and intracellular lysosomes and endosomes. With the help of FA, DOX/PEG-FA/SWNTs tend to selectively attach onto cancer cells and enter the lysosomes or endosomes by clathrin-mediated endocytosis. This can greatly improve the pharmaceutical efficiency and reduce potential side effects.",

keywords = "Biocompatibility, Drug delivery system, Folic acid (FA), Poly(ethylene glycol) (PEG), Single walled carbon nanotubes (SWNTs)",

author = "Lvye Niu and Lingjie Meng and Qinghua Lu",

year = "2013",

month = jun,

doi = "10.1002/mabi.201200475",

language = "英语",

volume = "13",

pages = "735--744",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "6",

}

TY - JOUR

T1 - Folate-conjugated PEG on single walled carbon nanotubes for targeting delivery of doxorubicin to cancer cells

AU - Niu, Lvye

AU - Meng, Lingjie

AU - Lu, Qinghua

PY - 2013/6

Y1 - 2013/6

N2 - A highly effective drug carrier is constructed by coating folic acid-terminated poly(ethylene glycol) (PEG-FA) on single walled carbon nanotubes (SWNTs) in a facile non-covalent method. The anti-cancer drug, doxorubicin (DOX), is further loaded on the surface of SWNTs at a very high loading efficiency, 149.3±4.1%. The drug system (DOX/PEG-FA/SWNTs) exhibits excellent stability under neutral pH conditions such as serum, but dramatically releases DOX at reduced pH typical of the tumour environment and intracellular lysosomes and endosomes. With the help of FA, DOX/PEG-FA/SWNTs tend to selectively attach onto cancer cells and enter the lysosomes or endosomes by clathrin-mediated endocytosis. This can greatly improve the pharmaceutical efficiency and reduce potential side effects.

AB - A highly effective drug carrier is constructed by coating folic acid-terminated poly(ethylene glycol) (PEG-FA) on single walled carbon nanotubes (SWNTs) in a facile non-covalent method. The anti-cancer drug, doxorubicin (DOX), is further loaded on the surface of SWNTs at a very high loading efficiency, 149.3±4.1%. The drug system (DOX/PEG-FA/SWNTs) exhibits excellent stability under neutral pH conditions such as serum, but dramatically releases DOX at reduced pH typical of the tumour environment and intracellular lysosomes and endosomes. With the help of FA, DOX/PEG-FA/SWNTs tend to selectively attach onto cancer cells and enter the lysosomes or endosomes by clathrin-mediated endocytosis. This can greatly improve the pharmaceutical efficiency and reduce potential side effects.

KW - Biocompatibility

KW - Drug delivery system

KW - Folic acid (FA)

KW - Poly(ethylene glycol) (PEG)

KW - Single walled carbon nanotubes (SWNTs)

UR - https://www.scopus.com/pages/publications/84879438789

U2 - 10.1002/mabi.201200475

DO - 10.1002/mabi.201200475

M3 - 文章

C2 - 23616476

AN - SCOPUS:84879438789

SN - 1616-5187

VL - 13

SP - 735

EP - 744

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 6

ER -

Folate-conjugated PEG on single walled carbon nanotubes for targeting delivery of doxorubicin to cancer cells

Abstract

Keywords

UN SDGs

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