Abstract
A new flow injection chemiluminescence method is described for the determination of ethamsylate. The method is based on the measurement of the chemiluminescence signal produced from oxidation of ethamsylate by potassium permanganate in acidic solution, enhanced by formic acid. The method allows the determination of ethamsylate over the range 1.0 x 10-8-2.0 x 10-6 g ml-1 with a sample measurement frequency of 180 samples h-1. The detection limit for ethamsylate is 5 x 10-9 g ml-1 and the relative standard deviation is 1.4% for 5.0 x 10-7 g ml-1 ethamsylate solution in eleven replicate measurements. The method was successfully applied to the determination of ethamsylate in pharmaceutical preparations. A brief discussion on the chemiluminescence reaction mechanism has also given.
| Original language | English |
|---|---|
| Pages (from-to) | 463-472 |
| Number of pages | 10 |
| Journal | Analytical Letters |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- Chemiluminescence
- Ethamsylate
- Flow injection
- Potassium permanganate