Factors related to the influence on congenital malformation of body surface in Shaanxi province

Objective To investigate the influencing factors on congenital malformation of body surface. Methods Multi-stage stratified random sampling method was adopted. A questionnaire survey was conducted among the childbearing aged women who experienced more than 28 weeks pregnancy or having definite pregnancy outcomes in Shaanxi, during 2010-2013. Results Results from the logistic regression model showed that factors as: intrahepatic cholestasis of pregnancy (OR= 21.76, 95%CI: 4.46-106.25), histories with abnormal pregnancy or reproduction (OR= 11.88, 95%CI: 9.14-15.45), having birth defects in the family (OR = 6.15, 95% C7: 2.66-14.23), being twins (OR = 5.74, 95% CI: 3.34-9.86), being worker (compared with others, OR = 2.47, 95% CI: 1.30-4.68) or farmer (compared with others, 0/2=1.91, 95%CI: 1.14-3.20), less than 4 times of antenatal care (compared with >7, OR =1.84, 95% CI: 1.28-2.64), occupational exposure to related risks during pregnancy (OR =1.74, 95%CI: 1.26-2.42), mother's hometown was from mid-part of Shaanxi (compared with northern Shaanxi, OR=1.65, 95%CI: 1.20-2.28), mother's native residence was from the rural areas (OR=1.75, 95% CI: 1.13-2.71), drug use (OR=1.64, 95% CI: 1.26-2.13) etc. were risk factors for congenital malformation of body surface. Iron supplement during pregnancy (OR = 0.46, 95% CI: 0.21-0.99) appeared as protective factor for congenital malformation of body surface. Conclusion The following factors seemed to be of risk for congenital malformation of body surface, including: mother's native area was from the middle part of Shaanxi and living in rural area, being worker or farmer, histories of abnormal pregnancy and reproduction, history of birth defects in the family, being twins, with antenatal care less than 4 times, occupational exposure to dangerous materials, drug use, intrahepatic cholestasis during pregnancy etc.