Fabrication of silver ordered nanoarrays SERS-active substrates and their applications in bladder cancer cells detection

  • You Liu
  • , Li Qing Huang
  • , Jun Wang
  • , Hui Min Tong
  • , Lin Yuan
  • , Li Hua Zhao
  • , Wei Wei Zhang
  • , Lei Wang
  • , Jian Zhu

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Highly ordered silver nanopore and nanocap arrays, which were used as surface-enhanced Raman scattering active (SERS-active) substrates, were fabricated by electron-beam evaporating silver on the surface of porous layer and barrier layer of porous anodic alumina (PAA) membranes, respectively. The SERS characteristics of the SERS-active substrates were tested with bladder cancer cells as molecular probe. The results indicated that both the SERS-active substrates displayed a strong SERS enhancement effect. The silver nanocap ordered arrays SERS-active substrate displayed not only higher SERS and fluorescence quenching effect, but also no interferential spectrum related with oxalate impurity remaining in PAA membranes, and therefore can result in the high quality Raman spectroscopy of bladder cancer cells.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalGuang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis
Volume32
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • Bladder caner cell
  • Porous anodic alumina
  • Silver ordered nanoarrays
  • Surface-enhanced Raman scattering

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