Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

Lin Lin Li; Yan Qi Zhang; Nan Jing Hao; Dong Chen; Fang Qiong Tang

doi:10.1007/s11434-012-5246-4

Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

Lin Lin Li
, Yan Qi Zhang
, Nan Jing Hao
, Dong Chen
, Fang Qiong Tang

CAS - Technical Institute of Physics and Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods, in-situ polymerization method and water in oil in water (W/O/W) double emulsion method, to coat a nanosized poly(lactic-co-glycolic acid) (PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle (PLGA@SN). The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.

Original language	English
Pages (from-to)	3631-3638
Number of pages	8
Journal	Chinese Science Bulletin
Volume	57
Issue number	27
DOIs	https://doi.org/10.1007/s11434-012-5246-4
State	Published - Sep 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

PLGA
docetaxel
drug delivery
in-situ copolymerization
microemulsion
silica nanorattle

Access to Document

10.1007/s11434-012-5246-4

Cite this

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title = "Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior",

abstract = "Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods, in-situ polymerization method and water in oil in water (W/O/W) double emulsion method, to coat a nanosized poly(lactic-co-glycolic acid) (PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle (PLGA@SN). The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.",

keywords = "PLGA, docetaxel, drug delivery, in-situ copolymerization, microemulsion, silica nanorattle",

author = "Li, \{Lin Lin\} and Zhang, \{Yan Qi\} and Hao, \{Nan Jing\} and Dong Chen and Tang, \{Fang Qiong\}",

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doi = "10.1007/s11434-012-5246-4",

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journal = "Chinese Science Bulletin",

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T1 - Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

AU - Li, Lin Lin

AU - Zhang, Yan Qi

AU - Hao, Nan Jing

AU - Chen, Dong

AU - Tang, Fang Qiong

PY - 2012/9

Y1 - 2012/9

N2 - Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods, in-situ polymerization method and water in oil in water (W/O/W) double emulsion method, to coat a nanosized poly(lactic-co-glycolic acid) (PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle (PLGA@SN). The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.

AB - Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods, in-situ polymerization method and water in oil in water (W/O/W) double emulsion method, to coat a nanosized poly(lactic-co-glycolic acid) (PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle (PLGA@SN). The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.

KW - PLGA

KW - docetaxel

KW - drug delivery

KW - in-situ copolymerization

KW - microemulsion

KW - silica nanorattle

UR - https://www.scopus.com/pages/publications/84866065693

U2 - 10.1007/s11434-012-5246-4

DO - 10.1007/s11434-012-5246-4

M3 - 文章

AN - SCOPUS:84866065693

SN - 1001-6538

VL - 57

SP - 3631

EP - 3638

JO - Chinese Science Bulletin

JF - Chinese Science Bulletin

IS - 27

ER -

Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

Abstract

UN SDGs

Keywords

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