Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres

Ke Wang; Jian Feng Xing; Xing Yi Li; Qiang Fu; Wei Feng Li

doi:10.1016/j.carbpol.2011.11.063

Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres

Ke Wang
, Jian Feng Xing
, Xing Yi Li
, Qiang Fu
, Wei Feng Li

Health Science Center

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In this paper, P(styrene-itaconic acid-divinylbenzene) microspheres (P(St-IA-DVB) microspheres) based on styrene (St), itaconic acid (IA) and divinylbenzene (DVB) were prepared via water-in-oil emulsions method (W/O) in the presence of emulsifiers with the size of 5-10 μm. The magnetic nanoparticles (i.e. Fe₃O₄) coated tightly on the surface of P(St-IA-DVB) microspheres were prepared in water with a continuous stirring. The morphology of blank microspheres and magnetic nanoparticles-coated microspheres was investigated in this work. In vitro drug release behavior was studied using doxorubicin as a model drug, and these magnetic nanoparticles-coated P(St-IA-DVB) (MNPSID) microspheres might have great potential application in magnetically targeted and thermal therapy.

Original language	English
Pages (from-to)	2712-2717
Number of pages	6
Journal	Carbohydrate Polymers
Volume	87
Issue number	4
DOIs	https://doi.org/10.1016/j.carbpol.2011.11.063
State	Published - 1 Mar 2012

Keywords

Magnetic nanoparticles
Magnetically targeted therapy
Microspheres

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10.1016/j.carbpol.2011.11.063

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title = "Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres",

abstract = "In this paper, P(styrene-itaconic acid-divinylbenzene) microspheres (P(St-IA-DVB) microspheres) based on styrene (St), itaconic acid (IA) and divinylbenzene (DVB) were prepared via water-in-oil emulsions method (W/O) in the presence of emulsifiers with the size of 5-10 μm. The magnetic nanoparticles (i.e. Fe3O4) coated tightly on the surface of P(St-IA-DVB) microspheres were prepared in water with a continuous stirring. The morphology of blank microspheres and magnetic nanoparticles-coated microspheres was investigated in this work. In vitro drug release behavior was studied using doxorubicin as a model drug, and these magnetic nanoparticles-coated P(St-IA-DVB) (MNPSID) microspheres might have great potential application in magnetically targeted and thermal therapy.",

keywords = "Magnetic nanoparticles, Magnetically targeted therapy, Microspheres",

author = "Ke Wang and Xing, \{Jian Feng\} and Li, \{Xing Yi\} and Qiang Fu and Li, \{Wei Feng\}",

year = "2012",

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doi = "10.1016/j.carbpol.2011.11.063",

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volume = "87",

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journal = "Carbohydrate Polymers",

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TY - JOUR

T1 - Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres

AU - Wang, Ke

AU - Xing, Jian Feng

AU - Li, Xing Yi

AU - Fu, Qiang

AU - Li, Wei Feng

PY - 2012/3/1

Y1 - 2012/3/1

N2 - In this paper, P(styrene-itaconic acid-divinylbenzene) microspheres (P(St-IA-DVB) microspheres) based on styrene (St), itaconic acid (IA) and divinylbenzene (DVB) were prepared via water-in-oil emulsions method (W/O) in the presence of emulsifiers with the size of 5-10 μm. The magnetic nanoparticles (i.e. Fe3O4) coated tightly on the surface of P(St-IA-DVB) microspheres were prepared in water with a continuous stirring. The morphology of blank microspheres and magnetic nanoparticles-coated microspheres was investigated in this work. In vitro drug release behavior was studied using doxorubicin as a model drug, and these magnetic nanoparticles-coated P(St-IA-DVB) (MNPSID) microspheres might have great potential application in magnetically targeted and thermal therapy.

AB - In this paper, P(styrene-itaconic acid-divinylbenzene) microspheres (P(St-IA-DVB) microspheres) based on styrene (St), itaconic acid (IA) and divinylbenzene (DVB) were prepared via water-in-oil emulsions method (W/O) in the presence of emulsifiers with the size of 5-10 μm. The magnetic nanoparticles (i.e. Fe3O4) coated tightly on the surface of P(St-IA-DVB) microspheres were prepared in water with a continuous stirring. The morphology of blank microspheres and magnetic nanoparticles-coated microspheres was investigated in this work. In vitro drug release behavior was studied using doxorubicin as a model drug, and these magnetic nanoparticles-coated P(St-IA-DVB) (MNPSID) microspheres might have great potential application in magnetically targeted and thermal therapy.

KW - Magnetic nanoparticles

KW - Magnetically targeted therapy

KW - Microspheres

UR - https://www.scopus.com/pages/publications/84865645636

U2 - 10.1016/j.carbpol.2011.11.063

DO - 10.1016/j.carbpol.2011.11.063

M3 - 文章

AN - SCOPUS:84865645636

SN - 0144-8617

VL - 87

SP - 2712

EP - 2717

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

IS - 4

ER -

Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres

Abstract

Keywords

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