Expression of TLR2 mRNA and TLR4 mRNA in psoriatic lesions

Objective: To detect the expression of toll-like receptor 2 (TLR2) mRNA and toll-like receptor 4 (TLR4) mRNA in psoriatic skin lesions. Methods: By using in situ hybridization, TLR2 mRNA and TLR4 mRNA expression levels were detected in psoriatic lesional and normal skin tissues. Results: TLR2 mRNA and TLR4 mRNA were highly expressed in the suprabasal layer of psoriatic lesions, while in normal epidermis TLR2 mRNA and TLR4 mRNA were expressed in the basal layer of epidermis. There was a significant difference between psoriatic lesion and the normal epiderm (P<0.05), and TLR2 mRNA and TLR4 mRNA expressions were higher in psoriatic lesional epidermis than in the normal epidermis. Conclusion: TLR2 and TLR4 may play a crucial role in the pathogenesis and development of psoriasis.