Expression of PTEN protein in primary lung cancer

Objective: To study the protein expression level and clinical significance of the tumor suppressor gene PTEN in primary lung cancer. Methods: We detected the protein expression of PTEN gene in paraffin specimens of 56 cases of lung cancer and 3 specimens of normal lung tissues by SP immunohistochemistry. Results: Circled digit one The positive rate of PTEN protein expression was higher in normal lung tissues than in lung cancer specimens, while it was lower in SCLC than in NSCLC. Circled digit two The positive rate of expression of PTEN protein became lower as the differentiation level decreased in the 56 cases of lung cancer specimens. Circled digit three The positive rate of expression of PTEN protein was higher in patients with lung cancer of stage I and II than that in stage III and IV. Circled digit four The positive rate of expression of PTEN protein was 26.32% in 19 cases of transfused specimens, which was obviously lower than that in non-transfused specimens. Conclusion: The expression of PTEN gene is related to classification criteria of lung cancer, malignancy degree, clinical stage and lymph node transfusion.