Expression of laminin and laminin receptor in gestational trophoblastic tumor and its significance

Objective: This study was conducted to detect the expression of laminin (LN) and laminin receptor (LN-R) in the specimens of hydatidiform mole (HM), invasive mole (IM) and choriocarcinoma(CC), respectively. Methods: The immunohistological staining method was used. Results: It was found that the level of laminin expression was higher in the specimens of choriocarcinoma at more advarced stage. Conclusion: The results suggest that there may be relations between the invasion and metastasis oE choriocacinoma cell and the malignant degree of this disease, chemotherapy has some effect on the expression o:i LN and LN-R in gestational trophablastic tumor (GTT), and that LN and LN-R may be of potential value in GTT treatment. However, referring whether LN and LN-R could be used as clinical prognos ticators, further studies will be needed.