Abstract
Objective: To study the expression of enhancer of zeste homolog 2 (EZH2) gene in cervical cancer and its significance. Methods: The expression of EZH2 mRNA was detected by RT-PCR in 20 samples of normal cervical tissues and 60 samples of cervical cancer tissues, and the relationship between EZH2 expression and the clinico-pathological features of cervical cancer was analyzed. Results: EZH2 mRNA had a higher expression in cervical cancer than in normal tissues (0.86±0.17 vs. 0.06±0.02, P<0.01). Furthermore, the condition of EZH2 expression was correlated with pathological grade, clinical stage, muscular invasion depth and lymph node metastasis of cervical cancer (P<0.05), but not with patients' age or tumor size (P>0.05). Conclusion: Increased expression of EZH2 gene might play an important role in malignant growth and be related to poor prognosis of cervical cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 758-760 |
| Number of pages | 3 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 32 |
| Issue number | 6 |
| State | Published - Nov 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Cervical cancer
- Enhancer of zeste homolog 2 (EZH2)
- Gene expression
- RT-PCR
Fingerprint
Dive into the research topics of 'Expression of EZH2 gene in cervical cancer and its significance'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver