Abstract
A new model of atherosclerosis cell membrane chromatography has been established by using a CD40 cell membrane stationary phase (CD40 CMSP) prepared by immobilizing the CD40 cell membrane onto the surface of a silica carrier. The surface and chromatographic characteristics of CD40 CMSP were studied. The retention characteristics of anti-CD40 antibody and statins (lovastatin, simvastatin and pravastatin) were also investigated using this model. Affinities of the anti-CD40 antibody and statins toward CD40 cell membrane and receptors were based on the determination of log k′ values (the logarithm of capacity factor of a solute). There was a significant correlation between the affinity in the CD40-CMC and the effect in vitro for the pharmacological effect.
| Original language | English |
|---|---|
| Pages (from-to) | 829-831 |
| Number of pages | 3 |
| Journal | Chromatographia |
| Volume | 67 |
| Issue number | 9-10 |
| DOIs | |
| State | Published - May 2008 |
Keywords
- Atherosclerosis
- CD40
- Cell membrane chromatography
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