Engineering the surface of Gd2O3 nanoplates for improved T1-weighted magnetic resonance imaging

Wen Cai; Yang Zhang; Junqing Wang; Zhiyong Wang; Ye Tian; Heng Liu; Hongzhi Pan; Li Fu; Wei Chen; Chunsheng Wu; Xiaoyong Wang; Gang Liu

doi:10.1016/j.cej.2019.122473

Engineering the surface of Gd₂O₃ nanoplates for improved T1-weighted magnetic resonance imaging

Wen Cai
, Yang Zhang
, Junqing Wang
, Zhiyong Wang
, Ye Tian
, Heng Liu
, Hongzhi Pan
, Li Fu
, Wei Chen
, Chunsheng Wu
, Xiaoyong Wang
, Gang Liu

Health Science Center

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The oleic acid (OA) and oleylamine (OM)-capped Gd₂O₃ nanoplates were encapsulated into N-Dodecyl-PEI-PEG polymer to synthesize the hydrophilic clusters for T1-weighted magnetic resonance imaging (MRI). The obtained Gd₂O₃@N-Dodecyl-PEI-PEG clusters showed a hydrodynamic size of 95 nm and a r1 value of 14.13 mM⁻¹ s⁻¹, which was approximately 4 times greater than that of the commercial product gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) (r1 = 3.40 mM⁻¹ s⁻¹). The in vitro toxicity demonstrated that the obtained clusters were biocompatible. The MRI experiments on SCC-7 cells/xenograft tumors indicated that the clusters had obvious T1-enhancement ability. These clusters have great potential application as T1-weighted MRI contrast agents.

Original language	English
Article number	122473
Journal	Chemical Engineering Journal
Volume	380
DOIs	https://doi.org/10.1016/j.cej.2019.122473
State	Published - 15 Jan 2020

Keywords

Biocompatible
Cluster
GdO nanoplates
Magnetic resonance imaging (MRI)

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10.1016/j.cej.2019.122473

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@article{23166e278fc04765a47d912ab1a009a0,

title = "Engineering the surface of Gd2O3 nanoplates for improved T1-weighted magnetic resonance imaging",

abstract = "The oleic acid (OA) and oleylamine (OM)-capped Gd2O3 nanoplates were encapsulated into N-Dodecyl-PEI-PEG polymer to synthesize the hydrophilic clusters for T1-weighted magnetic resonance imaging (MRI). The obtained Gd2O3@N-Dodecyl-PEI-PEG clusters showed a hydrodynamic size of 95 nm and a r1 value of 14.13 mM−1 s−1, which was approximately 4 times greater than that of the commercial product gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) (r1 = 3.40 mM−1 s−1). The in vitro toxicity demonstrated that the obtained clusters were biocompatible. The MRI experiments on SCC-7 cells/xenograft tumors indicated that the clusters had obvious T1-enhancement ability. These clusters have great potential application as T1-weighted MRI contrast agents.",

keywords = "Biocompatible, Cluster, GdO nanoplates, Magnetic resonance imaging (MRI)",

author = "Wen Cai and Yang Zhang and Junqing Wang and Zhiyong Wang and Ye Tian and Heng Liu and Hongzhi Pan and Li Fu and Wei Chen and Chunsheng Wu and Xiaoyong Wang and Gang Liu",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2020",

month = jan,

day = "15",

doi = "10.1016/j.cej.2019.122473",

language = "英语",

volume = "380",

journal = "Chemical Engineering Journal",

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TY - JOUR

T1 - Engineering the surface of Gd2O3 nanoplates for improved T1-weighted magnetic resonance imaging

AU - Cai, Wen

AU - Zhang, Yang

AU - Wang, Junqing

AU - Wang, Zhiyong

AU - Tian, Ye

AU - Liu, Heng

AU - Pan, Hongzhi

AU - Fu, Li

AU - Chen, Wei

AU - Wu, Chunsheng

AU - Wang, Xiaoyong

AU - Liu, Gang

PY - 2020/1/15

Y1 - 2020/1/15

N2 - The oleic acid (OA) and oleylamine (OM)-capped Gd2O3 nanoplates were encapsulated into N-Dodecyl-PEI-PEG polymer to synthesize the hydrophilic clusters for T1-weighted magnetic resonance imaging (MRI). The obtained Gd2O3@N-Dodecyl-PEI-PEG clusters showed a hydrodynamic size of 95 nm and a r1 value of 14.13 mM−1 s−1, which was approximately 4 times greater than that of the commercial product gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) (r1 = 3.40 mM−1 s−1). The in vitro toxicity demonstrated that the obtained clusters were biocompatible. The MRI experiments on SCC-7 cells/xenograft tumors indicated that the clusters had obvious T1-enhancement ability. These clusters have great potential application as T1-weighted MRI contrast agents.

AB - The oleic acid (OA) and oleylamine (OM)-capped Gd2O3 nanoplates were encapsulated into N-Dodecyl-PEI-PEG polymer to synthesize the hydrophilic clusters for T1-weighted magnetic resonance imaging (MRI). The obtained Gd2O3@N-Dodecyl-PEI-PEG clusters showed a hydrodynamic size of 95 nm and a r1 value of 14.13 mM−1 s−1, which was approximately 4 times greater than that of the commercial product gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) (r1 = 3.40 mM−1 s−1). The in vitro toxicity demonstrated that the obtained clusters were biocompatible. The MRI experiments on SCC-7 cells/xenograft tumors indicated that the clusters had obvious T1-enhancement ability. These clusters have great potential application as T1-weighted MRI contrast agents.

KW - Biocompatible

KW - Cluster

KW - GdO nanoplates

KW - Magnetic resonance imaging (MRI)

UR - https://www.scopus.com/pages/publications/85070584534

U2 - 10.1016/j.cej.2019.122473

DO - 10.1016/j.cej.2019.122473

M3 - 文章

AN - SCOPUS:85070584534

SN - 1385-8947

VL - 380

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

M1 - 122473

ER -

Engineering the surface of Gd₂O₃ nanoplates for improved T1-weighted magnetic resonance imaging

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Keywords

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