Engineering physical microenvironment for stem cell based regenerative medicine

Yu Long Han; Shuqi Wang; Xiaohui Zhang; Yuhui Li; Guoyou Huang; Hao Qi; Belinda Pingguan-Murphy; Yinghui Li; Tian Jian Lu; Feng Xu

doi:10.1016/j.drudis.2014.01.015

Engineering physical microenvironment for stem cell based regenerative medicine

Yu Long Han
, Shuqi Wang
, Xiaohui Zhang
, Yuhui Li
, Guoyou Huang
, Hao Qi
, Belinda Pingguan-Murphy
, Yinghui Li
, Tian Jian Lu
, Feng Xu

School of Life Science and Technology (SLST)

Xi'an Jiaotong University
Harvard University
University of Malaya
China Astronaut Research and Training Center

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.

Original language	English
Pages (from-to)	763-773
Number of pages	11
Journal	Drug Discovery Today
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.drudis.2014.01.015
State	Published - Jun 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.drudis.2014.01.015

Cite this

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title = "Engineering physical microenvironment for stem cell based regenerative medicine",

abstract = "Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.",

author = "Han, \{Yu Long\} and Shuqi Wang and Xiaohui Zhang and Yuhui Li and Guoyou Huang and Hao Qi and Belinda Pingguan-Murphy and Yinghui Li and Lu, \{Tian Jian\} and Feng Xu",

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doi = "10.1016/j.drudis.2014.01.015",

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TY - JOUR

T1 - Engineering physical microenvironment for stem cell based regenerative medicine

AU - Han, Yu Long

AU - Wang, Shuqi

AU - Zhang, Xiaohui

AU - Li, Yuhui

AU - Huang, Guoyou

AU - Qi, Hao

AU - Pingguan-Murphy, Belinda

AU - Li, Yinghui

AU - Lu, Tian Jian

AU - Xu, Feng

PY - 2014/6

Y1 - 2014/6

N2 - Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.

AB - Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.

UR - https://www.scopus.com/pages/publications/84902080514

U2 - 10.1016/j.drudis.2014.01.015

DO - 10.1016/j.drudis.2014.01.015

M3 - 文献综述

C2 - 24508818

AN - SCOPUS:84902080514

SN - 1359-6446

VL - 19

SP - 763

EP - 773

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 6

ER -

Engineering physical microenvironment for stem cell based regenerative medicine

Abstract

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