Abstract
A sensitive electrochemical detection scheme for morphine has been proposed by utilizing the ordered mesoporous carbon modified glassy carbon electrode (OMC/GCE). The electrochemical behaviour of morphine at the OMC/GCE was investigated by cyclic voltammetry. The modified electrode displayed a decrease in the overpotential (ca. 82 mV) and an obvious increase in the peak current (80 times) compared to the bare glassy carbon electrode (GCE). The results indicated that OMC/GCE remarkably enhanced electrocatalytic activity towards the oxidation of morphine. Linear response was found over the range from 0.1 μM to 20 μM with a high sensitivity of 1.74 μA/μM and low detection limit of 10 nM (S/N = 3). And the relative standard deviation was 0.86% (n = 5). Moreover, combining with a medium-exchange procedure, the OMC/GCE has also been successfully applied to the selective determination of morphine in urine samples with a low detection limit of 50 nM and satisfied recovery of 96.4%. The good results indicate that the OMC/GCE holds great promise in practical application.
| Original language | English |
|---|---|
| Pages (from-to) | 1408-1413 |
| Number of pages | 6 |
| Journal | Biosensors and Bioelectronics |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| State | Published - 15 Feb 2010 |
| Externally published | Yes |
Keywords
- Electrochemical determination
- Morphine
- Ordered mesoporous carbon
- Urine sample