Abstract
OBJECTIVE: To investigate the effects of methylcobalamin, gliclazide and their combination on peripheral nerve function and polyol pathway in streptozotocin diabetic rats. METHODS: The diabetic rats induced by streptozotocin intraperitoneal injection were administerted orally for 8 weeks. Effects of drugs on sciatic nerve morphological alterations, motor nerve conduction velocity, Na+, K+-ATPase activity and aldose reductase activity, sciatic nerve polyol contents were determined respectively. RESULTS: Compared with diabetic group, the sciatic nerve morphological alterations was improved, sciatic nerve conduction velocity increased, aldose reductase activity depressed and Na+, K+-ATPase activity increased in each group, respectively. The sorbitol and fructose contents were decreased in combination group. The glucose contents were reduced in gliclazide and combination groups. CONCLUSION: Methylcobalamin, gliclazide and their combination improve metabolism and function of peripheral nerve in streptozotocin diabetic rats. Synergistic action on polyol pathway was observed in drug combination group.
| Original language | English |
|---|---|
| Pages (from-to) | 27-30 |
| Number of pages | 4 |
| Journal | Chinese Pharmaceutical Journal |
| Volume | 39 |
| Issue number | 1 |
| State | Published - Jan 2004 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Diabetic peripheral neuropathy
- Gliclazide
- Methylcobalamin
- Polyol pathway
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