Abstract
Objective: To investigate the proliferative response and time course of endogenous neural stem/ progenitor cells after cerebral cortical concis in the adult rats. Methods: Eighty adult male Sprague-Dawley rats were used in this study. Cumulative BrdU labeling was employed to detect the proliferating cells. At 1 d, 3 d, 7 d, 14 d, and 21 d after cerebral cortical concis, the rats were killed for BrdU immunohistochemical staining and cell counting in the injured ipsilateral SVZ. Results: Little BrdU immunoreactivity cells was present in SVZ of the control rats from day 7 to day 21 after sham operation. The number of BrdU immunoreactivity cells in the injured ipsilateral SVZ increased at day 1 and peaked at day 7 after cerebral cortical concis. Conclusion: After cerebral cortical concis of the adult rats, neural stem/progenitor cells in the injured ipsilateral SVZ markedly proliferated with a peak at day 7. This finding may be important for manipulating SVZ cells to promote the recovery from cerebral cortical concis.
| Original language | English |
|---|---|
| Pages (from-to) | 191-194 |
| Number of pages | 4 |
| Journal | Academic Journal of Xi'an Jiaotong University |
| Volume | 18 |
| Issue number | 2 |
| State | Published - Nov 2006 |
Keywords
- Brain injury
- Nenrogenesis
- Neural progenitor cells
- Neural stem cells
- Rat
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