Abstract
Objective: To investigate the effect of total flavonoid of Herba Pyrolae (TFHP) on the changes of ECG in rats with acute myocardial ischemia as well as the mechanism of the action. Methods: Acute myocardial ischemic model was established by intravenous injection of Pituitrin in rats, and ECG was recorded. Acute myocardial infarction model was established by the ligation of left descending coronary artery in rats, and serum level of nitric oxide (NO) and free fatty acid (FFA) was determined with spectrophotometrical method besides ECG. Results: In comparison with the model controls, TFHP antagonized the decreased T wave by pituitrin and ligating coronary artery, and increased NO level and reduced FFA concentration in the scrum of rats with acute myocardial ischemia. Conclusion: TFHP protects the myocardium from ischemic injury possibly through increasing NO release and decreasing FFA production.
| Original language | English |
|---|---|
| Pages (from-to) | 581-583+630 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 31 |
| Issue number | 5 |
| State | Published - Sep 2010 |
Keywords
- Free fatty acid (FFA)
- Myocardial ischemia
- Nitric oxide (NO)
- Total flavonoids of Herbal Pyrola