Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis

Guizuo Wang; Yonghong Zhang; Xinming Xie; Dong Han; Yuanyuan Wu; Shaojun Li; Fengjuan Li; Manxiang Li

Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis

Guizuo Wang
, Yonghong Zhang
, Xinming Xie
, Dong Han
, Yuanyuan Wu
, Shaojun Li
, Fengjuan Li
, Manxiang Li

Health Science Center

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

OBJECTIVE: To systematically review whether statins can reduce the risk of infection and infection-related mortality.

METHODS: We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.

RESULTS: Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).

CONCLUSION: Statins can significantly reduce the risk of infection but does not lower infection-related mortality.

Original language	English
Pages (from-to)	988-993
Number of pages	6
Journal	Nan Fang Yi Ke Da Xue Xue Bao / Journal of Southern Medical University
Volume	34
Issue number	7
State	Published - 1 Jun 2014

Cite this

@article{1403f8226195483e980d5cafa5bd14ea,

title = "Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis",

abstract = "OBJECTIVE: To systematically review whether statins can reduce the risk of infection and infection-related mortality.METHODS: We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.RESULTS: Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95\% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95\% CI 0.82 to 1.12, P=0.592).CONCLUSION: Statins can significantly reduce the risk of infection but does not lower infection-related mortality.",

author = "Guizuo Wang and Yonghong Zhang and Xinming Xie and Dong Han and Yuanyuan Wu and Shaojun Li and Fengjuan Li and Manxiang Li",

year = "2014",

month = jun,

day = "1",

language = "英语",

volume = "34",

pages = "988--993",

journal = "Nan Fang Yi Ke Da Xue Xue Bao / Journal of Southern Medical University",

issn = "1673-4254",

publisher = "Nanfang Yi Ke Da Xue Xue Bao Bian ji Bu",

number = "7",

}

TY - JOUR

T1 - Effect of statins on occurrence of infection and infection-related mortality

T2 - a meta-analysis

AU - Wang, Guizuo

AU - Zhang, Yonghong

AU - Xie, Xinming

AU - Han, Dong

AU - Wu, Yuanyuan

AU - Li, Shaojun

AU - Li, Fengjuan

AU - Li, Manxiang

PY - 2014/6/1

Y1 - 2014/6/1

N2 - OBJECTIVE: To systematically review whether statins can reduce the risk of infection and infection-related mortality.METHODS: We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.RESULTS: Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).CONCLUSION: Statins can significantly reduce the risk of infection but does not lower infection-related mortality.

AB - OBJECTIVE: To systematically review whether statins can reduce the risk of infection and infection-related mortality.METHODS: We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.RESULTS: Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).CONCLUSION: Statins can significantly reduce the risk of infection but does not lower infection-related mortality.

UR - https://www.scopus.com/pages/publications/84941793002

M3 - 文章

C2 - 25057070

AN - SCOPUS:84941793002

SN - 1673-4254

VL - 34

SP - 988

EP - 993

JO - Nan Fang Yi Ke Da Xue Xue Bao / Journal of Southern Medical University

JF - Nan Fang Yi Ke Da Xue Xue Bao / Journal of Southern Medical University

IS - 7

ER -

Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis

Abstract

Other files and links

Fingerprint

Cite this