Effect of resveratrol on oxygen free radicals of multiple organs in rats with severe acute pancreatitis of early stage

Objective: To observe the effect of resveratrol on superoxide dismutase and malondialdehyde of multiple organs in rats with severe acute pancreatitis of early stage. Methods: A total of fifty-four rats were divided into three groups (sham group, SAP model group and resveratrol-treated group). SAP model was made by injecting sodium taurocholate 0.1 mL/100 g to the pancreatic bile duct, and resvoratrol was given intravenously. The rats were sacrificed at four hours after inducing SAP model. The levels of MDA and SOD and histological changes of pancreas, lungs, liver, kidneys and small intestines were measured. Results: The levels of MDA in pancreas, lungs, liver, kidneys and small intestine tissues in model group were significantly higher than those in sham group (P < 0.05), while the level of SOD was significantly lower in the tissues involved. The levels of SOD in pancreatic and lung tissues in resveratrol-treated group were significantly higher than those in model group, while the levels of MDA in pancreas, lungs, liver, kidneys and small intestines were significantly lower in the tissues concerned. Conclusion: Oxygen free radicals participate in the process of pathological changes in SAP. Resveratrol might increase SOD activity and decrease MDA level, thus attenuating lipid peroxidation in multiple organs of SAP, especially in pancreas and lung tissues.