Abstract
Objective: To investigate the effect of erythromycin (EM) on interdigestive migrating motor complex (MMC) in healthy volunteers. Methods: 20 healthy volunteers were randomly divided into 2 groups; EM group (n= 11) and placebo group (n=9). The changes of MMC were observed by gastrointestinal manometry before and after oral administration of EM or placebo. Results: Gastric antral MMCs that evoked by EM were similar to spontaneous MMCs. EM orally intaking decreased MMC cycle duration significantly (P<0.05). EM orally intaking decreased the Percentage of Phase II duration to MMC cycle duration significantly (P<0.05). But EM orally intaking increased the Percentage of Phase M duration to MMC cycle duration significantly (P<0.05). The amplitude of antral waves of Phase III increased significantly after EM orally intaking (P<0.05). Placebo orally intaking didn't affect MMC cycle duration, Propagation velocity of Phase III and Percentages of Phase I, Phase II, Phase III duration to MMC cycle duration. Conclusion: EM has stimulating effect on gastrointestinal motor activity.
| Original language | English |
|---|---|
| Pages (from-to) | 141-144 |
| Number of pages | 4 |
| Journal | Academic Journal of Xi'an Jiaotong University |
| Volume | 17 |
| Issue number | 2 |
| State | Published - Nov 2005 |
Keywords
- Erythromycin
- Gastrointestinal manometry
- Migrating motor complex