TY - JOUR
T1 - Determination of triflusal in human plasma by LC-MS/MS and its pharmacokinetics
AU - Peng, Li
AU - Ding, Li Kun
AU - Jia, Yan Yan
AU - Yang, Lin
AU - Ge, Jie
AU - Wang, Mao Hu
AU - Wen, Ai Dong
AU - Zhang, Jie
N1 - Publisher Copyright:
©, 2014, Chinese Journal of New Drugs Co. Ltd. All right reserved.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Objectives: To establish an LC-MS/MS method to determine the concentration of triflusal in human plasma, and to evaluate the pharmacokinetics of triflusal capsules in Chinese healthy volunteers. Methods: Thirty-six healthy volunteers were divided into three groups, taking 300, 600, and 900 mg triflusal capsules, respectively. After oral dose, the concentrations of triflusal in plasma were detected by LC-MS/MS and pharmacokinetics were evaluated. Results: Triflusal determinations in plasma were not interfered by the endogenous substances. The quantitative limit, precision, recovery rate, the matrix effect and stability were conform to the requirements of analysis in biological samples. The main pharmacokinetic parameters were: Tmax, 0.55, 0.61 and 0.67 h; Cmax, 3.31, 10.85 and 13.22 μg·mL-1; AUC0-10, 3.92, 13.18 and 19.51 mg·h·L-1. Conclusions: The method is simply, accurant and selective, and suitable for pharmacokinetic study of triflusal capsules.
AB - Objectives: To establish an LC-MS/MS method to determine the concentration of triflusal in human plasma, and to evaluate the pharmacokinetics of triflusal capsules in Chinese healthy volunteers. Methods: Thirty-six healthy volunteers were divided into three groups, taking 300, 600, and 900 mg triflusal capsules, respectively. After oral dose, the concentrations of triflusal in plasma were detected by LC-MS/MS and pharmacokinetics were evaluated. Results: Triflusal determinations in plasma were not interfered by the endogenous substances. The quantitative limit, precision, recovery rate, the matrix effect and stability were conform to the requirements of analysis in biological samples. The main pharmacokinetic parameters were: Tmax, 0.55, 0.61 and 0.67 h; Cmax, 3.31, 10.85 and 13.22 μg·mL-1; AUC0-10, 3.92, 13.18 and 19.51 mg·h·L-1. Conclusions: The method is simply, accurant and selective, and suitable for pharmacokinetic study of triflusal capsules.
KW - LC-MS/MS
KW - Pharmacokinetics
KW - Triflusal capsule
UR - https://www.scopus.com/pages/publications/84922603334
M3 - 文章
AN - SCOPUS:84922603334
SN - 1003-3734
VL - 24
SP - 27-30 and 73
JO - Chinese Journal of New Drugs
JF - Chinese Journal of New Drugs
IS - 1
ER -
